Results 211 to 220 of about 346,103 (330)

Socioeconomic position and clinical outcomes in patients with myelodysplastic syndromes: A population‐based cohort study

Hematological Oncology, Volume 40, Issue 5, Page 1056-1066, December 2022., 2022
Abstract Low socioeconomic position (SEP) may be associated with adverse outcomes in patients with myelodysplastic syndromes (MDS) inherent to for example, delayed diagnosis or reduced treatment intensity, but firm evidence is limited. In this study, we examined the association between SEP and clinical outcomes.
Tine Bichel Lauritsen, Lene Sofie Granfeldt Østgård, Kirsten Grønbæk, Susanne Oksbjerg Dalton, Jan Maxwell Nørgaard   +4 more
wiley   +1 more source

Engineering antibodies with cancer‐associated binding sites

BMEMat, EarlyView.
This review describes antibodies that perform direct/indirect roles in cancer treatment by binding to effective targets and discusses how antibodies kill tumors and modulate tumor microenvironment through these targets. The classification of expression systems for antibody production is summarized to guide appropriate selection based on different ...
Yinqi Tian, Yumeng Pan, Yingchun Zhang, Fangling Wang, Zejun Wang   +4 more
wiley   +1 more source

Germline selection of PTPN11 (HGNC:9644) variants make a major contribution to both Noonan syndrome's high birth rate and the transmission of sporadic cancer variants resulting in fetal abnormality

Human Mutation, Volume 43, Issue 12, Page 2205-2221, December 2022., 2022
Mutation frequency heat map of spontaneous PTPN11 variants show spatial clustering in the testis due to germline selection explaining the high birth incidence of Noonan syndrome. Some somatic PTPN11 cancer mutations are similarly clustered in testis. Abstract Some spontaneous germline gain‐of‐function mutations promote spermatogonial stem cell clonal ...
Jordan Eboreime, Soo‐Kyung Choi, Song‐Ro Yoon, Anastasiia Sadybekov, Vsevolod Katritch, Peter Calabrese, Norman Arnheim   +6 more
wiley   +1 more source

The Flow Cytometric Evaluation of B- and T-Lymphoblastic Leukemia/Lymphoma. [PDF]

Cancers (Basel)
Dorfman DM.
europepmc   +1 more source

5‐Aza combined with VPA reprograms human T lineage acute leukemia Jurkat cells into B‐cell‐like cells by epigenetic activation of PAX5

Biotechnology Progress, EarlyView.
Abstract Epigenetic regulation plays an important role in cell fate reprogramming. Here, we found that inhibitors of epigenetic modifiers, including VPA, TSA, and 5‐Aza‐2'‐deoxycytidine, can induce phenotypic transformation from Jurkat cells into B‐cell‐like cells. When Jurkat cells were treated with 5‐Aza combined with VPA, B cell and stem cell marker
Wenjin Xi, Guoxu Zheng, Xu Chen, Baile Zuo, Wei Wang, Yufang Li, Chunmei Zhang, Jie Chu, Xiuli Mu, Weihong Wen, Tao Wang, An‐Gang Yang   +11 more
wiley   +1 more source

Associations between early‐life and in utero infections and cytomegalovirus‐positive acute lymphoblastic leukemia in children

International Journal of Cancer, Volume 152, Issue 5, Page 845-853, 1 March 2023., 2023
What's new? Cytomegalovirus (CMV) infection early in life likely contributes to the development of childhood acute lymphoblastic leukemia (ALL), owing to CMV‐induced alterations in immune function. In the present study, the relationship between risk of childhood ALL and exposure to CMV in utero or early life was investigated among children with ALL who
Rachel E. Gallant, Katti Arroyo, Catherine Metayer, Alice Y. Kang, Adam J. de Smith, Joseph L. Wiemels   +5 more
wiley   +1 more source

Identification of leukemia-enriched signature through the development of a comprehensive pediatric single-cell atlas. [PDF]

Nat Commun
Mumme HL, Huang C, Ohlstrom D, Bakhtiari M, Raikar SS, DeRyckere D, Qayed M, Castellino SM, Wechsler DS, Porter CC, Graham DK, Bhasin SS, Bhasin M.   +12 more
europepmc   +1 more source

Exposures to pesticides and risk of cancer: Evaluation of recent epidemiological evidence in humans and paths forward

International Journal of Cancer, Volume 152, Issue 5, Page 879-912, 1 March 2023., 2023
Abstract Knowledge of the role in cancer etiology of environmental exposures as pesticides is a prerequisite for primary prevention. We review 63 epidemiological studies on exposure to pesticides and cancer risk in humans published from 2017 to 2021, with emphasis on new findings, methodological approaches, and gaps in the existing literature.
Haleigh Cavalier, Leonardo Trasande, Miquel Porta   +2 more
wiley   +1 more source

Network-based clustering unveils interconnected landscapes of genomic and clinical features across myeloid malignancies. [PDF]

Nat Commun
Bayer F, Roncador M, Moffa G, Morita K, Takahashi K, Beerenwinkel N, Kuipers J.   +6 more
europepmc   +1 more source

Incidence of childhood leukemia before and after shut down of nuclear power plants in Germany in 2011: A population‐based register study during 2004 to 2019

International Journal of Cancer, Volume 152, Issue 5, Page 913-920, 1 March 2023., 2023
What's new? The association between leukemia and proximity to nuclear power plants has been assessed in several countries with inconsistent results. Here, using an ecological study design, the authors found that the incidence of leukemia slightly decreased among children aged <15 living near nuclear power plants in Germany where at least one reactor ...
Antonello Russo, Maria Blettner, Hiltrud Merzenich, Daniel Wollschlaeger, Friederike Erdmann, Emilio Gianicolo   +5 more
wiley   +1 more source