Results 241 to 250 of about 400,118 (290)

Semi‐mechanistic population PK/PD model to aid clinical understanding of myelodysplastic syndromes following treatment with Venetoclax and Azacitidine

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 448-459, March 2025.
Abstract Myelodysplastic syndromes (MDS) represent a group of bone marrow disorders involving cytopenias, hypercellular bone marrow, and dysplastic hematopoietic progenitors. MDS remains a challenge to treat due to the complex interplay between disease‐induced and treatment‐related cytopenias.
Neha Thakre, Corinna Maier, Jiuhong Zha, Benjamin Engelhardt, Johannes E. Wolff, Sven Mensing   +5 more
wiley   +1 more source

Extensive myeloid sarcoma presenting with esophageal compression and dysphagia as the initial manifestation. [PDF]

Medicine (Baltimore)
Li H, Dai L, Wang X, Yu Y.
europepmc   +1 more source

Disease–Drug–Drug Interaction of Imatinib in COVID‐19 ARDS: A Pooled Population Pharmacokinetic Analysis

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 583-595, March 2025.
ABSTRACT Prior pharmacokinetic (PK) analysis revealed that increased alpha‐1‐acid glycoprotein (AAG) levels are associated with decreased imatinib unbound fraction in coronavirus disease 2019 (COVID‐19) patients. This study aimed to investigate the PK of total and unbound concentrations of imatinib and the metabolite N‐desmethyl imatinib in ...
Medhat M. Said, Job R. Schippers, Leila Atmowihardjo, Yingxue Li, Mick S. van der Plas, Harm J. Bogaard, Lieuwe D. J. Bos, Ron A. A. Mathôt, Jurjan Aman, Eleonora L. Swart, Imke H. Bartelink   +10 more
wiley   +1 more source

Plasma levels of soluble podoplanin are higher in acute promyelocytic leukemia compared to other forms of acute myeloid leukemia. [PDF]

Hematol Transfus Cell Ther
Moraes CRP, Saraiva CMA, Borba-Junior IT, Duarte BKL, de Campos PM, Saad STO, De Paula EV.   +6 more
europepmc   +1 more source

Advances in Elemene Nanodelivery Systems: From Material Design to Disease Treatment

Rare Metals, EarlyView.
ABSTRACT Elemene (ELE) is a bioactive sesquiterpenoid extracted from traditional Chinese herbs, demonstrating broad‐spectrum antitumor, anti‐inflammatory, and analgesic properties with significant therapeutic potential. However, its clinical utility is constrained by inherent physicochemical limitations, including volatility and hydrophobicity, which ...
Xiao Wang, Jiatong Lin, Yi Peng, Zehua Wu, Yingying Liu, Wei Duan, Qiaolin Wei, Jia‐Wei Shen, Jiang‐Xing Chen, Yong Guo   +9 more
wiley   +1 more source

Leukemic Transdifferentiation: From Pathological Plasticity to Dendritic Cell-Based Immunotherapy. [PDF]

Biomedicines
Dubis J, Czogalla A, Kuliczkowski K, Sikorski AF.   +3 more
europepmc   +1 more source

Non-steroidal Anti-inflammatory Drug-Induced Severe Eosinophilia and Hematogone Hyperplasia Masquerading as Leukemia: Diagnostic Complexity in a Young Child. [PDF]

Cureus
Saxena S, Singh S, Radhakrishnan N.
europepmc   +1 more source

Patient characteristics, burden of disease, healthcare resource utilization and costs in acute myeloid leukemia - a retrospective observational study with German claims data. [PDF]

J Comp Eff Res
Greth K, Lehne M, Ghiani M, Mevius A, Purcell S, Kaulfuss S, Gokhale M, Russell A.   +7 more
europepmc   +1 more source

High TERF2 expression is associated with poor prognosis and its suppression attenuates progression in acute myeloid leukemia. [PDF]

Transl Cancer Res
Yao L, Wang X.
europepmc   +1 more source

Acute myeloid leukemia with bipotential erythroid and megakaryocytic differentiation: a case series and literature review. [PDF]

J Hematop
Liu LW, De Lancy SJ, Hurwitz SN.
europepmc   +1 more source