Results 21 to 30 of about 166,676 (142)
Haematologica, 2014 Acute myeloid leukemia with t(6;9)(p22;q34) is listed as a distinct entity in the 2008 World Health Organization classification, but little is known about the clinical implications of t(6;9)-positive myeloid leukemia in children.
Julie Damgaard Sandahl +27 more
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Frontiers in Immunology, 2022 Acute myeloid leukemia is the most common acute leukemia in adults, with accumulation of abundant blasts and impairment of hematogenic function. Despite great advances in diagnosis and therapy, the overall survival of patients with acute myeloid leukemia
Xianfeng Ouyang +2 more
doaj +1 more source
Hierarchy in Gene Expression is Predictive for Adult Acute Myeloid Leukemia [PDF]
, 2015 Cancer progresses with a change in the structure of the gene network in normal cells. We define a measure of organizational hierarchy in gene networks of affected cells in adult acute myeloid leukemia (AML) patients. With a retrospective cohort analysis based on the gene expression profiles of 116 acute myeloid leukemia patients, we find that the ...
arxiv +1 more source
Progression, Detection and Remission: Evolution of Chronic Myeloid Leukemia using a three-stage probabilistic model [PDF]
arXiv, 2022 We present a three-stage probabilistic model for the progression of Chronic Myeloid Leukemia (CML), as manifested by the leukemic stem cells, progenitor cells and mature leukemic cells. This progression is captured through the process of cell division and cell mutation, with probabilities of occurrence being assigned to both of them.
arxiv
Studying the age of onset and detection of Chronic Myeloid Leukemia using a three-stage stochastic model [PDF]
arXiv, 2022 Chronic Myeloid Leukemia (CML) is a biphasic malignant clonal disorder that progresses, first with a chronic phase, where the cells have enhanced proliferation only, and then to a blast phase, where the cells have the ability of self-renewal. It is well-recognized that the Philadelphia chromosome (which contains the BCR-ABL fusion gene) is the ...
arxiv
Clonal selection and therapy resistance in acute leukemias: Mathematical modelling explains different proliferation patterns at diagnosis and relapse [PDF]
J. R. Soc Interface 11(94):20140079, 2014, 2013 Recent experimental evidence suggests that acute myeloid leukemias may originate from multiple clones of malignant cells. Nevertheless it is not known how the observed clones may differ with respect to cell properties such as proliferation and self-renewal. There are scarcely any data on how these cell properties change due to chemotherapy and relapse.
arxiv +1 more source
Entropy of leukemia on multidimensional morphological and molecular landscapes [PDF]
Phys. Rev. X 4, 021038 (2014), 2014 Leukemia epitomizes the class of highly complex diseases that new technologies aim to tackle by using large sets of single-cell level information. Achieving such goal depends critically not only on experimental techniques but also on approaches to interpret the data.
arxiv +1 more source
Біологічні студії, 2014 The exposition of α1-acid glycoprotein and fibronectin on the surface and inside the lymphocytes of healthy donors and hematological patients with acute and chronic myeloid leukemia were studied.
G. S. Маslak
doaj +1 more source
Early Risk Prediction of Chronic Myeloid Leukemia with Protein Sequences using Machine Learning-based Meta-Ensemble [PDF]
arXiv, 2023 Leukemia, the cancer of blood cells, originates in the blood-forming cells of the bone marrow. In Chronic Myeloid Leukemia (CML) conditions, the cells partially become mature that look like normal white blood cells but do not resist infection effectively.
arxiv
Induction of microRNAs, mir-155, mir-222, mir-424 and mir-503, promotes monocytic differentiation through combinatorial regulation [PDF]
Leukemia. 24 (2010) 460-6, 2010 Acute myeloid leukemia (AML) involves a block in terminal differentiation of the myeloid lineage and uncontrolled proliferation of a progenitor state. Using phorbol myristate acetate (PMA), it is possible to overcome this block in THP-1 cells (an M5-AML containing the MLL-MLLT3 fusion), resulting in differentiation to an adherent monocytic phenotype ...
arxiv +1 more source