Results 21 to 30 of about 838,442 (361)

Cytoplasmic mutated nucleophosmin is stable in primary leukemic cells and in a xenotransplant model of NPMc+ acute myeloid leukemia in SCID mice

Haematologica, 2008
We investigated the NPM1 mutation status or subcellular expression of NPM protein (nuclear vs. aberrant cytoplasmic) at diagnosis and relapse in 125 patients with acute myeloid leukemia from Italy and Germany.
Brunangelo Falini, Maria Paola Martelli, Cristina Mecucci, Arcangelo Liso, Niccolò Bolli, Barbara Bigerna, Alessandra Pucciarini, Stefano Pileri, Giovanna Meloni, Massimo F. Martelli, Torsten Haferlach, Susanne Schnittger   +11 more
doaj   +1 more source

YBX1 is required for maintaining myeloid leukemia cell survival by regulating BCL2 stability in an m6A-dependent manner.

Blood, 2021
RNA-binding proteins (RBPs) are critical regulators of transcription and translation that are often dysregulated in cancer. Although RBPs are increasingly appreciated as being important for normal hematopoiesis and for hematological malignancies as ...
Mengdie Feng, Xueqin Xie, G-X Han, Tiantian Zhang, Yashu Li, Yicun Li, Rong Yin, Qifan Wang, Tongnian Zhang, Peipei Wang, Jin Hu, Ying Cheng, Zhuying Gao, Jing Wang, Jiwei Chang, Manman Cui, Ke-Ke Gao, Jihua Chai, Weidong Liu, Chengli Guo, Shaoguang Li, Lingbo Liu, F. Zhou, Jianjun Chen, Haojian Zhang   +24 more
semanticscholar   +1 more source

Comparison of genetic and clinical aspects in patients with acute myeloid leukemia and myelodysplastic syndromes all with more than 50% of bone marrow erythropoietic cells

Haematologica, 2011
Background The World Health Organization separates acute erythroid leukemia (erythropoiesis in ≥50% of nucleated bone marrow cells; ≥20% myeloblasts of non-erythroid cells) from other entities with increased erythropoiesis – acute myeloid leukemia with ...
Ulrike Bacher, Claudia Haferlach, Tamara Alpermann, Wolfgang Kern, Susanne Schnittger, Torsten Haferlach   +5 more
doaj   +1 more source

Chronic myeloid leukemia stem cells display alterations in expression of genes involved in oxidative phosphorylation [PDF]

, 2012
The mitochondrial respiratory chain (MRC) consists of protein complexes I, II, III, IV and V that support oxidative phosphorylation (OXPHOS), which depends on electron transport to generate adenosine triphosphate (ATP).
Flis, Krzysztof, Skorski, Tomasz, Bhatia, Ravi, Irvine, David, Bhatia, R., Copland, Mhairi, Irvine, D., Copland, M., Skorski, T., Flis, K.   +9 more
core   +1 more source

Genomic Classification and Prognosis in Acute Myeloid Leukemia

New England Journal of Medicine, 2016
Background Recent studies have provided a detailed census of genes that are mutated in acute myeloid leukemia (AML). Our next challenge is to understand how this genetic diversity defines the pathophysiology of AML and informs clinical practice.
E. Papaemmanuil, M. Gerstung, L. Bullinger, V. Gaidzik, P. Paschka, Nicola D. Roberts, N. Potter, M. Heuser, F. Thol, N. Bolli, G. Gundem, P. van Loo, I. Martincorena, P. Ganly, L. Mudie, Stuart McLaren, S. O’Meara, K. Raine, David Jones, J. Teague, A. Butler, M. Greaves, A. Ganser, K. Döhner, R. Schlenk, H. Döhner, P. Campbell   +26 more
semanticscholar   +1 more source

De novo Acute Myeloid Leukemia: A Population- based Study of Outcome in the United States Based on the Surveillance, Epidemiology, and End Results (SEER) Database, 1980–2017

Cancer, 2021
Several important treatment and supportive care strategies have been implemented over the past 4 decades in the management of acute myeloid leukemia (AML).
K. Sasaki, F. Ravandi, T. Kadia, C. Dinardo, N. Short, G. Borthakur, E. Jabbour, H. Kantarjian   +7 more
semanticscholar   +1 more source

Uncommon CD markers in acute myeloid leukemia

Bangabandhu Sheikh Mujib Medical University Journal, 2018
This study was done to assess the unusual CD expression in 100 cases of acute myeloid leukemia from October 2016 to April 2018. The age limit was from 3 to 50 years.
Azad Abul Kalam, Md. Rafiquzzaman Khan, A. B. M. Hassan Habib, Masuda Begum   +3 more
doaj   +1 more source

Acute Promyelocytic Leukemia Presenting With a Myeloid Sarcoma of the Spine: A Case Report and Literature Review

Frontiers in Oncology, 2022
Myeloid sarcoma is a rare extramedullary tumor of immature myeloid cells. Certain known acute myeloid leukemia cytogenetic abnormalities, in particular t(8,21), has been associated with a higher incidence.
Xuemei Shu, Qiuling Wu, Tao Guo, Hua Yin, Jingdi Liu   +4 more
doaj   +1 more source

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

New England Journal of Medicine, 2013
BACKGROUND Many mutations that contribute to the pathogenesis of acute myeloid leukemia (AML) are undefined. The relationships between patterns of mutations and epigenetic phenotypes are not yet clear.
T. Ley, C. Miller, L. Ding, Benjamin J. Raphael, A. Mungall, A. G. Robertson, K. Hoadley, T. Triche, P. Laird, J. Baty, L. Fulton, R. Fulton, S. Heath, Joelle M. Kalicki-Veizer, Cyriac Kandoth, J. Klco, D. Koboldt, K. Kanchi, S. Kulkarni, T. Lamprecht, D. Larson, Ling Lin, Charles Lu, M. McLellan, Joshua F. McMichael, J. Payton, Heather K. Schmidt, D. Spencer, M. Tomasson, J. Wallis, L. Wartman, M. Watson, J. Welch, M. Wendl, Adrian Ally, M. Balasundaram, I. Birol, Y. Butterfield, Readman Chiu, Andy Chu, E. Chuah, Hye-Jung E. Chun, R. Corbett, Noreen Dhalla, R. Guin, A. He, Carrie Hirst, M. Hirst, R. Holt, Steven P. Jones, A. Karsan, Darlene Lee, H. Li, M. Marra, Michael Mayo, Richard A. Moore, K. Mungall, J. Parker, E. Pleasance, Patrick Plettner, J. Schein, D. Stoll, Lucas Swanson, Angela Tam, N. Thiessen, R. Varhol, N. Wye, Yongjun Zhao, S. Gabriel, G. Getz, C. Sougnez, L. Zou, Mark D. M. Leiserson, Fabio Vandin, Hsin-Ta Wu, F. Applebaum, S. Baylin, Rehan Akbani, B. Broom, Ken Chen, Thomas C. Motter, Khanh Nguyen, J. Weinstein, Nian-Zhu Zhang, M. Ferguson, C. Adams, Aaron D. Black, Jay Bowen, J. Gastier-Foster, T. Grossman, T. Lichtenberg, L. Wise, Tanja Davidsen, J. Demchok, K. Shaw, Margi Sheth, H. Sofia, Liming Yang, J. Downing, G. Eley   +99 more
semanticscholar   +1 more source

Targeting C-type lectin-like molecule-1 for antibody-mediated immunotherapy in acute myeloid leukemia

Haematologica, 2010
Background C-type lectin-like molecule-1 is a transmembrane receptor expressed on myeloid cells, acute myeloid leukemia blasts and leukemic stem cells.
Xiaoxian Zhao, Shweta Singh, Cecile Pardoux, Jingsong Zhao, Eric D. Hsi, Arie Abo, Wouter Korver   +6 more
doaj   +1 more source