Results 141 to 150 of about 1,294,431 (344)
Advanced Science, EarlyView.This study reveals that histone lactylation, a modification derived from lactate, plays a crucial role in ferroptosis resistance in ectopic endometrial stromal cells. This resistance is mediated via the HIF1A/HMOX1 pathway regulated by METTL3. In vivo, a combination of 2‐DG and erastin shows promise as an effective treatment for endometriosis ...
Zongwen Liang +8 more
wiley +1 more source
LEUKEMIA OF ADULT MICE CAUSED BY A TRANSMISSIBLE AGENT [PDF]
, 1957 Charlotte Friend
openalex +1 more source
Advanced Science, EarlyView.In this study, Acod1 knockout in CLP mice significantly increases peripheral blood NET levels, exacerbating inflammation, organ damage, and reducing survival. Further research shows that UBR5 interacts with PAD4, a key NET formation protein. Acod1/itaconate (ITA) enhances the enzymatic activity of UBR5 by alkylating the Cys2768 site, promoting the K48 ...
Huifan Liu +10 more
wiley +1 more source
From Patient to Practitioner [PDF]
, 2012 After a brutal battle with leukemia, Robert Lisac ’12 plans to spend his career in the hospital – this time as the doctor, not the ...
Davis, Laura
core +1 more source
P769: MUTATION PROFILES AND RISK STRATIFICATION IN HYPOCELLULAR MYELODYSPLASTIC SYNDROME
HemaSphere, 2022 K. Kim +13 more
doaj +1 more source
Leukemia and Exposure to X-Ray: A Report of 6 Cases [PDF]
, 1959 William C. Moloney
openalex +1 more source
USP10 Inhibits Ferroptosis via Deubiquinating POLR2A in Head and Neck Squamous Cell Carcinoma
Advanced Science, EarlyView.This study identifies USP10 as a novel deubiquitinase that antagonizes ferroptosis in head and neck squamous cell carcinoma (HNSCC). Mechanistically, USP10 directly stabilizes POLR2A protein through post‐translational deubiquitination, enabling POLR2A‐mediated transcriptional activation of SLC7A11, a key ferroptosis inhibitor.
Diekuo Zhang +13 more
wiley +1 more source