Results 111 to 120 of about 69,360 (221)

The Hsp90β Isoform: An Attractive Target for Drug Development

Medicinal Research Reviews, EarlyView.
ABSTRACT The beta isoform of 90 kDa heat shock protein (Hsp90β) plays a critical role in maintaining cellular proteostasis by assisting in the folding and refolding of proteins, which is essential for both normal cellular function and stress response.
Subhabrata Chaudhury, Terin D'Amico, Brian S. J. Blagg   +2 more
wiley   +1 more source

A Focus on Natural Autophagy Modulators as Potential Host‐Directed Weapons Against Emerging and Re‐Emerging Viruses

Medicinal Research Reviews, EarlyView.
ABSTRACT Autophagy is a highly conserved intracellular process involved in maintaining homeostasis and in the degradation of damaged organelles and external pathogens. Nature provides complex and varied reservoirs of scaffolds and chemical entities that may have a pivotal role in the search for new therapeutic leads.
Ilaria Cursaro, Sara Rossi, Stefania Butini, Sandra Gemma, Gabriele Carullo, Giuseppe Campiani   +5 more
wiley   +1 more source

Role of astrocyte in neuroinflammation‐induced loss in neuroplasticity and subsequent onset of depression: A systematic review

Neuroprotection, EarlyView.
Mechanistic crosstalk between microglia and astrocytes in major depressive disorder. Abstract Major depressive disorder (MDD) is a complex psychiatric condition increasingly linked to chronic neuroinflammation, particularly in the context of aging, stress, and systemic comorbidities.
Gaurav Singhal, Saurabh Singhal, Bernhard T. Baune   +2 more
wiley   +1 more source

Analysis of IDH1 and IDH2 mutations as causes of the hypermethylator phenotype in colorectal cancer

The Journal of Pathology, EarlyView.
Abstract The CpG island methylator phenotype (CIMP) occurs in many colorectal cancers (CRCs). CIMP is closely associated with global hypermethylation and tends to occur in proximal tumours with microsatellite instability (MSI), but its origins have been obscure.
Joseph C Ward, Melissa Morgan, James Wood, Connor Woolley, Albert Antao Nobre de Menezes, Alina Finch, Kitty Sherwood, Qiwen Huang, Chloe S Henry, Juan Fernández‐Tajes, Ignacio Soriano, Steve Thorn, Isabelle Legge, James McCullagh, David Kerr, Rachel Kerr, Rahul K Hejmadi, Mark J Arends, The S:CORT Consortium, Richard Adams, Simon Bach, Andrew Beggs, Louise Brown, Francesca Buffa, Jean‐Baptiste Cazier, Enric Domingo, Andrew Blake, Che‐Hsi Wu, Ekaterina Chatzpili, Susan Richman, Philip Dunne, Paul Harkin, Geoff Higgins, Jim Hill, Chris Holmes, Denis Horgan, Rick Kaplan, Richard Kennedy, Mark Lawler, Simon Leedham, Ultan McDermott, Gillies McKenna, Gary Middleton, Dion Morton, Graeme Murray, Philip Quirke, Manuel Salto‐Tellez, Les Samuel, Anna Schuh, David Sebag‐Montefiore, Matt Seymour, Ricky Sharma, Richard Sullivan, Ian Tomlinson, Nicholas West, Richard Wilson, Enric Domingo, Timothy Maughan, Chiara Bardella, Ian Tomlinson   +59 more
wiley   +1 more source

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

Augmented 3D Printing for Multiscale Microphysiological Systems

Small, EarlyView.
This review explores augmented 3D printing techniques combined with multiscale ancillary methods to overcome current limitations in fabricating complex microphysiological systems (MPS). It covers 3D printing and ancillary techniques, and highlights advancements in augmented MPS that surpass conventional systems, offering more physiologically relevant ...
Kyeong Seob Hwang, Jiyoung Song, Hyun Wook Kang, Jongbaeg Kim, Cheol Woo Ha, Nakwon Choi, Seokyoung Bang, Hong Nam Kim   +7 more
wiley   +1 more source

Near‐Infrared‐Triggered Nanodroplets for Imaging‐Guided Macrophage‐Mediated Cancer Immunotherapy

Small Methods, EarlyView.
Schematic illustration of the Nanodroplets and their theranostics application–The engineered nanodroplets integrate a multifunctional design, encapsulating the immunostimulant resiquimod (R848), indocyanine green (ICG), and volatile perfluoropentane (PFP), within a biocompatible double‐emulsion structure.
Junxi Yi, Meenakshi Chauhan, Yang Zhao, Yun‐Sheng Chen   +3 more
wiley   +1 more source

Rapid and Sensitive Detection of RNA Viruses through Imaging of Marker Molecules Derived from Designed Circular DNA Probes

Small Methods, EarlyView.
This study presents a rapid and sensitive virus detection method that employs imaging of virus‐specific DNA markers. Utilizing specially designed single‐stranded circular DNA probes, this method captures RNA fragments from RNase‐digested viral genomes during the reverse transcriptase‐based reaction, resulting in double‐stranded markers that are ...
Yoon‐ha Jang, Taesoo Kim, Su‐jin Hong, Se‐yeon Kim, Hyeseung Hwang, Siwon Kim, Su‐a Kang, Nabin Won, Dogeun Kim, Min Jae Kim, Yong Pil Chong, Seongsoo Jang, Kyubong Jo, Kwang‐il Lim   +13 more
wiley   +1 more source

The murine leukemia-sarcoma virus complex. [PDF]

Proceedings of the National Academy of Sciences, 1967
openaire   +3 more sources

Nanomedicine for Oral Delivery: Strategies to Overcome the Biological Barriers

Small Methods, EarlyView.
Oral delivery is a preferred administration route for many clinical applications, valued for its strong patient compliance. In this review, how nanoparticles are engineered and deployed to overcome the gastrointestinal barriers that impede clinical translation of oral delivery formulations is examined.
Luke J. Kubiatowicz, Nima Pourafzal, Audrey T. Zhu, Zhongyuan Guo, Ronnie H. Fang, Liangfang Zhang   +5 more
wiley   +1 more source