Results 121 to 130 of about 69,360 (221)

An Integrated Method to Evaluate the Treatment Efficacy and Immunogenicity of B‐Cell Acute Lymphoblastic Leukemia Therapeutic Enzyme Formulations

Small Methods, EarlyView.
This work presents an integrated set of methods to evaluate the efficacy of asparaginase formulations against B‐cell Acute Lymphoblastic Leukemia (ALL) in mice, including the establishment of an ALL murine model, an amino acid depletion study using high‐performance liquid chromatography (HPLC), and comprehensive assessment of antibody production ...
Julien Santelli, Annie Y. Heble, Connor Endsley, Adam Woodward, Nazia Hafeez, Naomi Winick, Jacques Lux   +6 more
wiley   +1 more source

CRISPR/Cas9‐edited tumor‐associated immune cells in cancer immunotherapy

VIEW, EarlyView.
Abstract Immuno‐oncology represents an emerging field that has significantly transformed tumor therapeutics, with immune cells serving as the cellular foundations of cancer immunotherapy. Due to its high efficiency and sensitivity, CRISPR/Cas9 genome editing is a highly promising technique for precise and rapid gene modification.
Yuhui Ma, Junxin Chen, Yuan Du, Zhihao Cao, Weizhi Ji, Yuyu Niu, Zebin Yang   +6 more
wiley   +1 more source

Correction: Antibody Responses against Xenotropic Murine Leukemia Virus-Related Virus Envelope in a Murine Model.

PLoS ONE, 2011
Natalia Makarova, Chunxia Zhao, Yuanyuan Zhang, Sushma Bhosle, Suganthi Suppiah, Jeanne M. Rhea, Natalia Kozyr, Rebecca S. Arnold, Hinh Ly, Ross J. Molinaro, Tristram G. Parslow, Eric Hunter, Dennis Liotta, John Petros, Jerry L. Blackwell   +14 more
doaj   +3 more sources

Herpes simplex virus‐1 infection alters microtubule‐associated protein Tau splicing and promotes Tau pathology in neural models of Alzheimer's disease

Brain Pathology, EarlyView.
HSV‐1 infection alters MAPT splicing and promotes Tau pathology in neural models of Alzheimer's disease. HSV‐1 infection in brain organoids and neuronal models increase 4R‐MAPT splicing and Tau hyperphosphorylation. HSV‐1 ICP27 is both necessary and sufficient for inducing these changes highlighting the potential role of HSV‐1 in Alzheimer's disease ...
Emmanuel C. Ijezie, Michael J. Miller, Celine Hardy, Ava R. Jarvis, Timothy F. Czajka, Lianna D'Brant, Natasha Rugenstein, Adam Waickman, Eain Murphy, David C. Butler   +9 more
wiley   +1 more source

Clonal Hematopoiesis and Solid Cancers

Cancer Science, EarlyView.
This review explores the relationship between clonal hematopoiesis and solid cancers. Clonal hematopoiesis mutations influence the tumor microenvironment by altering immune regulation, inflammation, and angiogenesis. Understanding these mutations has important clinical implications, including their role in prognosis, treatment response, and potential ...
Yen T. M. Nguyen, Manabu Fujisawa, Shumpei Ishikawa, Mamiko Sakata‐Yanagimoto   +3 more
wiley   +1 more source

Human sporadic breast carcinoma histotypes driven by the Human Betaretrovirus homologous to Mouse Mammary Tumor Virus. [PDF]

Int J Cancer
What's new? While estrogens, obesity, and alcohol are recognized risk factors for breast cancer, a viral hypothesis has been suggested based on the murine model of Mouse Mammary Tumor Virus (MMTV)‐induced mammary tumors. This study analyzed sequences of the human homolog of MMTV across human breast carcinoma histotypes, detecting the virus in all types
Civita P, Mazzanti CM, Lessi F, Marchiò C, Scatena C, Menicagli M, Ghilli M, Roncella M, Naccarato AG, Sapino A, Hochman J, Pistello M, Bevilacqua G.   +12 more
europepmc   +2 more sources

The Role of Histone Methyltransferase SETDB1 in Normal and Malignant Hematopoiesis

Cancer Science, EarlyView.
In this review, we discuss the role of SETDB1 in gene regulation, including an overview of its structural features and key cofactors. We also highlight the lineage‐specific roles of SETDB1 in both normal hematopoietic processes and hematological malignancies, emphasizing its function as an immune checkpoint molecule that suppresses natural killer cell ...
Yu‐Hsuan Chang, Susumu Goyama
wiley   +1 more source

Advances in the Study of Pluripotent Stem Cells in Livestock

Cell Proliferation, EarlyView.
Livestock pluripotent stem cells include embryonic stem cells (ESCs) isolated from the inner cell mass of blastocysts and induced pluripotent stem cells (iPSCs) derived from somatic cell reprogramming. They hold significant potential for applications in livestock breed improvement, rapid propagation, human disease modelling and human organ ...
Xinyi Zhou, Chen Gao, Wenxuan Zhao, Xinhua Wei, Dawei Yu, Huiying Zou, Weihua Du   +6 more
wiley   +1 more source

Dual Role of Natural Killer Cells in Early Pregnancy: Immunopathological Implications and Therapeutic Potential in Recurrent Spontaneous Abortion and Recurrent Implantation Failure

Cell Proliferation, EarlyView.
This article elaborates on the role of NK cells in early pregnancy from multiple perspectives, including molecular mechanisms and therapeutic interventions. It also discusses how NK cell dysfunction contributes to RSA and RIF, aiming to provide insights for future research on NK cell mechanisms and clinical treatment of RSA and RIF.
Defeng Guan, Zhou Chen, Yuhua Zhang, Wenjie Sun, Lifei Li, Xia Huang   +5 more
wiley   +1 more source

Maternal Nutritional Status Governs Fetal Development by Modulating Imprinting Gene GAB1‐Mediated Trophoblast Differentiation in the Placenta

Cell Proliferation, EarlyView.
Maternal nutrient restriction disrupts placental homeostasis via GAB1 dysregulation—involving both transcriptional downregulation and autophagy‐dependent protein degradation. These molecular alterations inhibit MAPK signalling‐mediated trophoblast fusion, leading to structural and functional deficits in the maternal–fetal exchange interface.
Mingming Fan, Hongyu Wu, Yuan Xie, Ming Liu, Xin Yu, Feiyang Wang, Zhenyu Xiao, Hongmei Wang, Xuan Shao, Yan‐Ling Wang   +9 more
wiley   +1 more source