Results 151 to 160 of about 166,376 (296)
Advances in Therapeutic Antibody Discovery and Development Targeting G Protein‐Coupled Receptors
ABSTRACT G protein‐coupled receptors (GPCRs) are integral to numerous biological processes and are associated with various diseases across all therapeutic areas. Consequently, GPCRs present substantial potential for antibody‐based therapies. This review offers an overview of the therapeutic GPCR‐antibody target landscape and examines the diversity ...
Catherine J. Hutchings +6 more
wiley +1 more source
Fifty Years of Natural Killer Cells: Milestones and Future Horizons
To mark 50 years of NK cell research, a 2025 Karolinska symposium traced discoveries from spontaneous cytotoxicity and “missing self” recognition to receptor biology, cellular diversity, and translational advances, highlighting NK cells’ evolution into modern immunotherapy.
Andreas Lundqvist +7 more
wiley +1 more source
This study integrates bulk and single‐cell RNA‐seq data to reveal significant B cell receptor (BCR) repertoire expansion, especially IgG isotype amplification, in T cell‐mediated rejection (TCMR) after kidney transplantation. Multi‐omic integration identifies plasma cells as the main BCR carriers in graft tissue and MEI1 as a key regulator promoting ...
He Zhang +5 more
wiley +1 more source
Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth +2 more
wiley +1 more source
Spleen-derived Rauscher Murine Leukemia Virus [PDF]
openaire +2 more sources
The pH‐sensitive His6‐SWNTs, which is functionalized with oligohistidine, can deliver STTM396 molecules into callus cells. The STTM396–SWNT complex treatments enhance shoot regeneration efficiency by regulating the miR396‐GRF module in Arabidopsis and tomato calli.
Yeong Yeop Jeong +7 more
wiley +1 more source

