Results 221 to 230 of about 166,376 (296)

2024 taxonomy update for the family Retroviridae. [PDF]

Arch Virol
Mayer J, Blanco-Melo D, Coffin JM, Gifford RJ, Johnson WE, Lindemann D, Peeters M, Sato K, Stoye J, Tachedjian G, Hatziioannou T.   +10 more
europepmc   +1 more source

STAT3 SH2 Domain Aspartic Acid 661 Mutations Activate Immune Gene Programs

Journal of Cellular and Molecular Medicine, Volume 30, Issue 1, January 2026.
ABSTRACT The conserved aspartic acid residue D661 within the STAT3 SH2 domain is a recurrent mutational hotspot in hematologic malignancies, including T‐cell large granular lymphocytic leukaemia, myelodysplastic syndromes and acute lymphoblastic leukaemia. To define the functional consequences of distinct STAT3D661 variants, we integrated computational,
Hye Kyung Lee, Gyuhyeok Cho, Jichun Chen, Aaron B. Schultz, Sung‐Gwon Lee, Chengyu Liu, Priscilla A. Furth, Neal S. Young, Jungwook Kim, Alejandro Villarino, Lothar Hennighausen   +10 more
wiley   +1 more source

Targeting S100A9-mediated inflammation: a novel therapeutic approach for CLL. [PDF]

Blood Adv
Uriepero-Palma A, Márquez ME, Payque E, Mediavilla-Varela M, Gamal W, Maharaj K, Powers J, Chavez J, Eksioglu E, Sernbo S, Palacios F, Querol-Rivas J, Ortega C, Uria R, Santos GD, Oliver C, Landoni AI, Sahakian E, Oppezzo P, Pinilla-Ibarz J.   +19 more
europepmc   +1 more source

Chimeric Antigen Receptor T‐Cell Therapy: More Than an Anti‐Cancer Drug

HLA, Volume 107, Issue 1, January 2026.
ABSTRACT Initially, chimeric antigen receptor (CAR) T‐cell therapy was developed to eliminate malignant B cells in haematological B‐cell malignancies by targeting CD19 and B‐cell maturation antigen. This approach achieved notable success, resulting in (malignant) B‐cell depletion and inducing clinical remission in cancer patients.
Hannah C. M. Schenk, Ilse Gille, Carolt Arana, Jordi Rovira, Eduard Palou, Fritz Diekmann, Dave L. Roelen, Mirjam H. M. Heemskerk, Sebastiaan Heidt   +8 more
wiley   +1 more source

Murine leukemia virus glycoGag antagonizes SERINC5 via ER-phagy receptor RETREG1. [PDF]

PLoS Pathog
Ahmad I, Zhang J, Li R, Su W, Liu W, Wu Y, Khan I, Liu X, Li LF, Li S, Zheng YH.   +10 more
europepmc   +1 more source

The Major Role of Type 2 Inflammation in Asthma: From the Perspective of Immunological Mechanism

BioMed Research International, Volume 2026, Issue 1, 2026.
Asthma is a heterogeneous disease that affects individuals of diverse age groups globally and exhibits variable responses to different treatments. Type 2 inflammation contributes to the pathogenesis of asthma through the production of cytokines IL‐4, IL‐5, and IL‐13, thereby inducing characteristic features of asthma such as elevated eosinophil levels ...
Lanying Cheng, Lihong Sun, Baisakhi Banerjee   +2 more
wiley   +1 more source

Innovative Colorimetric Neutral Red-Based Loop-Mediated Isothermal Amplification (NR-LAMP) Assay: Transforming Rapid and Affordable Feline Leukemia Virus Detection. [PDF]

Int J Mol Sci
Rapichai W, Khamsingnok P, Wachirachaikarn A, Laodim T, Dong HV, Meecharoen N, Ratanabunyong S, Khaoiam T, Tuanthap S, Rattanasrisomporn A, Pairor S, Choowongkomon K, Tansakul N, Lieberzeit PA, Rattanasrisomporn J.   +14 more
europepmc   +1 more source

Neutrophil Plasticity and NETosis in Tumour Microenvironment: Tumour Evolution and Therapy Resistance

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Neutrophil extracellular traps (NETs) are web‐like formations consisting of DNA‐histone complexes and associated proteins released from activated neutrophils. While NET formation plays an important role in innate immunity, it is also associated with the pathogenesis of autoimmune disorders such as rheumatoid arthritis, psoriasis and systemic lupus ...
Mojdeh Soltani, Sara Falahi, Mohammad Abbaszadeh, Mark J. M. Sullman, Hamed Fouladseresht, Nahid Eskandari, Poorani Gurumallesh   +6 more
wiley   +1 more source

High-resolution analysis of the human T-cell leukemia virus capsid protein reveals insights into immature particle morphology. [PDF]

Nat Commun
Arndt WG, Ramezani A, Talledge N, Yu G, Yang H, Chen B, Perilla JR, Zhang W, Mansky LM.   +8 more
europepmc   +1 more source