Results 31 to 40 of about 69,360 (221)

The tale of xenotropic murine leukemia virus-related virus

Journal of General Virology, 2012
In 2006, a new retrovirus was isolated from prostate cancer patient tissue. Named xenotropic murine leukemia virus-related virus (XMRV), this was potentially the third class of retrovirus to be pathogenic in humans. XMRV made a more dramatic impact on the wider scientific community, and indeed the media, in 2009 when it was reported to be present in a ...
Kate N. Bishop, Harriet C. T. Groom
openaire   +3 more sources

Characterizationof Murine Leukemia Virus Restriction inMammals [PDF]

Journal of Virology, 2003
ABSTRACT Restriction of murine leukemia virus (MLV) was examined in cells from a range of mammals. All nonmurine restrictions were saturable blocks to N-tropic MLV infection, and several were prior to reverse transcription. We demonstrate restriction in cells from bat and show that if we express the murine restriction factor Fv1 in human ...
Benjamin Strange, Laura M. J. Ylinen, Adrian M. Lister, Caroline Besnier, Stephen P. Goff, Yasuhiro Takeuchi, Greg J. Towers, Greg J. Towers   +7 more
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Testing Strategies for Detection of Xenotropic Murine Leukemia Virus-Related Virus Infection

Advances in Virology, 2011
Xenotropic murine leukemia virus-related virus (XMRV) is a newly identified gamma retrovirus and may be associated with prostate cancer- (PC) and chronic fatigue syndrome (CFS). Since its identification in 2006 and detection of polytropic murine lenkemia
Shixing Tang, Indira K. Hewlett
doaj   +1 more source

Tropism, Cytotoxicity, and Inflammatory Properties of Two Envelope Genes of Murine Leukemia Virus Type-Endogenous Retroviruses of C57BL/6J Mice

Mediators of Inflammation, 2011
Envelope (env) proteins of certain endogenous retroviruses (ERVs) participate in various pathophysiological processes. In this study, we characterized pathophysiologic properties of two murine leukemia virus-type ERV (MuLV-ERV) env genes cloned from the ...
Young-Kwan Lee, Alex Chew, David G. Greenhalgh, Kiho Cho   +3 more
doaj   +1 more source

Infection of XC cells by MLVs and Ebola virus is endosome-dependent but acidification-independent. [PDF]

PLoS ONE, 2011
Inhibitors of endosome acidification or cathepsin proteases attenuated infections mediated by envelope proteins of xenotropic murine leukemia virus-related virus (XMRV) and Ebola virus, as well as ecotropic, amphotropic, polytropic, and xenotropic murine
Haruka Kamiyama, Katsura Kakoki, Hiroaki Yoshii, Masatomo Iwao, Tsukasa Igawa, Hideki Sakai, Hideki Hayashi, Toshifumi Matsuyama, Naoki Yamamoto, Yoshinao Kubo   +9 more
doaj   +1 more source

Genetic predisposition to porto‐sinusoidal vascular disorder: A functional genomic‐based, multigenerational family study

Hepatology, EarlyView., 2022
A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan, André Megarbane, Aziz Chouchane, Deepak Karthik, Ramzi Temanni, Atilio Reyes Romero, Huiying Hua, Chun Pan, Xixi Chen, Murugan Subramanian, Chadi Saad, Hamdi Mbarek, Cybel Mehawej, Eliane Chouery, Sirin W. Abuaqel, Alexander Dömling, Sami Remadi, Cesar Yaghi, Pu Li, Lotfi Chouchane   +19 more
wiley   +1 more source

Structural basis of suppression of host translation termination by Moloney Murine Leukemia Virus

Nature Communications, 2016
Retroviral reverse transcriptase from Moloney Murine Leukemia Virus (MoMLV) requires interaction with peptidyl release factor 1. Here, the authors report the crystal structure of this complex, and provide insights into how MoMLV uses the host translation
Xuhua Tang, Yiping Zhu, Stacey L. Baker, Matthew W. Bowler, Benjamin Jieming Chen, Chen Chen, J. Robert Hogg, Stephen P. Goff, Haiwei Song   +8 more
doaj   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

The Abelson Murine Leukemia Virus Oncogene

Experimental Biology and Medicine, 1985
Abelson murine leukemia virus (A-MuLV) is an acute transforming retrovirus which induces a rapid lymphosarcoma in mice. The virus arose in one of a series of mice that were treated with prednisolone and infected with the replication-competent retrovirus Moloney murine leukemia virus (M-MuLV) (1, 2).
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Structure of the abelson murine leukemia virus genome

Cell, 1979
Virions produced from cells transformed by A-MuLV contain a 30S, 5.6 kb RNA that can be translated in a cell-free system to form the characteristic A-MuLV protein. This RNA was mapped by heteroduplex methods using DNA probes from M-MuLV, the presumed parent of A-MuLV.
Anthony Shields, Michael Paskind, Stephen P. Goff, David Baltimore, Gary Otto   +4 more
openaire   +3 more sources