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Leukocyte Disorders: Quantitative and Qualitative Disorders of the Neutrophil, Part 2
Pediatrics In Review, 1996The differential diagnosis for a patient presenting with recurrent infections is formidable, given the complexity of the immune system. The clinical presentation of a patient who has a qualitative neutrophil abnormality may be similar to that of one who has an antibody or complement disorder. In general, evaluation for phagocytic cell disorders (Table)
L A, Boxer, R A, Blackwood
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Clinical Disorders of Leukocyte Functions
1984After being questioned by a colleague about my current endeavors with a large number of reprints, reference printouts, and writing pads apparent, I informed him that I was writing another review on clinical abnormalities of phagocyte function. Why write another such review, I was asked, as there are a number of these in the current literature (Gallin ...
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Leukocyte Disorders: Quantitative and Qualitative Disorders of the Neutrophil, Part 1
Pediatrics In Review, 1996Introduction Neutrophils form the first line of defense against most bacterial and fungal pathogens after disruption of the skin and mucous membranes. Once tissue is invaded by microorganisms, a variety of vasoactive and chemotactic mediators are released by the involved tissue.
L A, Boxer, R A, Blackwood
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Human Leukocyte Antigen Type and Posttransplant Lymphoproliferative Disorder
Transplantation, 2015Posttransplant lymphoproliferative disorder (PTLD) is an infrequent but serious complication of solid organ transplantation. Early detection and initiation of therapy may improve outcomes. The purpose of this study was to identify human leukocyte antigen (HLA) type as risk and prognostic factors for PTLD.A review was undertaken to identify PTLD cases ...
Mark E, Lustberg +7 more
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Disorders of Leukocytes Leading to Recurrent Infection
Pediatric Clinics of North America, 1972Because they possess the unique property of phagocytosis, certain blood cells appear to be primarily responsible for host defense against pyogenic and fungal infection. The primary phagocyte of the peripheral blood is the polymorphonuclear neutrophil; its functions and their disorders are described in this paper.
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Retinal Blood Velocity in Patients With Leukocyte Disorders
Archives of Ophthalmology, 1988The blue light entoptic phenomenon was used to measure retinal blood velocity in eight patients with chronic granulocytic leukemia, six patients with leukopenia, and matched control subjects. The retinal leukocyte velocity of the leukemic patients was 0.53 +/- 0.26 (mean +/- SD) mm/s, whereas that of the matched control subjects was 0.46 +/- 0.14 mm/s.
T, Rimmer, E M, Kohner, J M, Goldman
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Leukocyte mitochondrial DNA copy number in bipolar disorder
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2014Evidence supports the role for mitochondrial impairment in the pathophysiology of bipolar disorder (BD). BD has been associated with decreased mitochondrial electron transport chain activity and increased oxidative stress. Also, mitochondrial DNA (mtDNA) encodes mitochondrial electron transport chain proteins and has been associated with altered ...
Rafael T, de Sousa +7 more
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Leukocyte-Related Disorders: A Review for the Pediatrician
Pediatric Annals, 2020Leukocytes, or white blood cells, are part of the innate immune system that defends against infectious and foreign agents. In pediatrics, it is important to use age-specific laboratory values when interpreting results. Infections are the most common cause of leukocytosis or leukopenia in children.
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Deletion of leukocyte mitochondrial DNA in bipolar disorder
Journal of Affective Disorders, 1996Leukocyte mitochondrial DNA (mtDNA) was examined in 35 patients with bipolar disorder by the nested PCR method to explore whether or not the 4977 base-pair deletion (common deletion) is found. The PCR product corresponding to the common deletion was found in 2 of 35 (5.7%) patients and none of 29 normal controls.
T, Kato, Y, Takahashi
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Physiological Roles of Leukocytes and Disorders
2018This chapter describes white blood cells of the peripheral blood: neutrophils, eosinophils, basophils, monocytes, and lymphocyte subsets. It describes their basic physiology and important disease states associated with defects of each of these entities. Each of these cells arises from a common bone marrow myeloid or lymphoid progenitor to differentiate
Jahnavi Gollamudi +2 more
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