Results 51 to 60 of about 1,587,061 (308)

Inflammatory polyradiculoneuropathies: Clinical and immunological aspects, current therapies, and future perspectives

European Journal of Inflammation, 2020
Inflammatory polyradiculoneuropathies are heterogeneous disorders characterized by immune-mediated leukocyte infiltration of peripheral nerves and nerve roots leading to demyelination or axonal degeneration or both.
Vincenzo Di Stefano, Filomena Barbone, Camilla Ferrante, Roberta Telese, Michela Vitale, Marco Onofrj, Antonio Di Muzio   +6 more
doaj   +1 more source

Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS‐CT1 Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau, Marie Bruguet, Irina Viakhireva‐Dovganyuk, François‐Mathias Merrien, Denis Marechal, Aurore Jourdain, Philippe Goas, Jordan Coris, Julien Asselineau, Maëlys Consigny, Gérald Le Gac, Serge Timsit   +11 more
wiley   +1 more source

TLR2-mediated leukocyte trafficking to the developing brain

, 2017
Inflammation is a significant risk factor for brain injury in the perinatal period. In this study, we tested the hypothesis that activation of peripheral TLR induces inflammation in the brain, including leukocyte trafficking.
Hagberg, Henrik,, Ek, C. Joakim,, Mallard, Carina,, Smith, Peter L P,, Mottahedin, Amin,   +4 more
core   +1 more source

Dissecting the limited genetic overlap of Parkinson's and Alzheimer's disease

Annals of Clinical and Translational Neurology, 2022
Parkinson's disease and Alzheimer's disease show overlapping features both clinically and neuropathologically and elucidating shared mechanisms could have important implications for therapeutic strategies.
Maren Stolp Andersen, Manuela Tan, Inge R. Holtman, John Hardy, International Parkinson's Disease Genomics Consortium, Lasse Pihlstrøm   +5 more
doaj   +1 more source

Predictive Value of Composite Inflammatory Markers for Stroke Prognosis: A Prospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Novel composite inflammatory markers' role in stroke prognosis is understudied, and the best predictor is unclear, requiring further exploration. Objectives This study aimed to systematically evaluate the associations of 6 novel composite inflammatory markers on stroke prognosis.
Bing Wu, Jie‐Jie Li, Jing Jing, Jin‐Xi Lin, Xia Meng, Yong Jiang, Yong‐Jun Wang, Hong‐Qiu Gu   +7 more
wiley   +1 more source

In-111-labeled Leukocyte Scintigraphy in Postoperative Joint Infection [PDF]

, 2000
To evaluate the role of In-111-labeled leukocyte scintigraphy in the patients with suspected postoperative joint infection, 41 scintigraphic examinations were performed in 24 patients. Scintigrams were interpreted by the degree of accumulation of labeled
Ogawa, Yoji, Uetani, Masataka, Hayashi, Kuniaki, Aziz, Aamer   +3 more
core  

Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-κB activation. [PDF]

, 2014
Pro-inflammatory cytokine-induced activation of nuclear factor, NF-κB has an important role in leukocyte adhesion to, and subsequent migration across, brain endothelial cells (BECs), which is crucial for the development of neuroinflammatory disorders ...
Susanne MA van der Pol, Male, David K, Cerutti, Camilla, Dongsheng Wu, van der Pol, SM, Sharrack, B, Michael, Gregory J, Simpson, Julie E., Lopez-Ramirez, Miguel A., David Baker, Romero, IA, Baker, David, Basil Sharrack, Simpson, Julie E, Michael, GJ, Wu, Dongsheng, van der Pol, Susanne M A, Hirst, Mark C, Julie E Simpson, Ignacio A Romero, Pryce, Gareth, Baker, D, Gregory J Michael, de Vries, Helga E, Romero, Ignacio A., Hirst, MC, King-Robson, Josh, de Vries, HE, Lopez-Ramirez, Alejandro, Mark C Hirst, David K Male, Male, DK, de Vries, Helga E., Gareth Pryce, Josh King-Robson, Camilla Cerutti, van der Pol, SMA, Romero, Ignacio A, Lopez-Ramirez, Miguel A, Male, David K., King-Robson, J, van der Pol, Susanne M. A., Wu, D, Simpson, JE, Lopez-Ramirez, MA, Miguel A Lopez-Ramirez, van der Pol, Susanne Ma, Cerutti, C, Helga E de Vries, Pryce, G, Hirst, Mark C., Sharrack, Basil, Michael, Gregory J.   +52 more
core   +1 more source

Causal Relationships Between Leukocyte Subsets and Adverse Fetal Outcomes: A Mendelian Randomization Study

Mediators of Inflammation
Conclusions: This study provided profound insights into the intricate regulatory mechanisms of leukocyte subsets in neonatal diseases, paving the way for new avenues in the diagnosis and treatment of associated disorders.
Hong Chen, Li-Zhen Shao, Ying-Xiong Wang, Zhi-Jie Han, Yong-Heng Wang, Xia Li, Jing-Yu Chen, Tai-Hang Liu   +7 more
doaj   +1 more source

Leukocyte Drumsticks in Chronic Granulocytic Leukemia and Related Disorders [PDF]

Blood, 1961
Abstract 1. The drumstick and other nuclear appendages of the nuclei of polymorphonuclear neutrophils from patients with chronic granulocytic leukemia (CGL), leukemoid reactions and inflammatory leukocytoses were studied. 2. The drumstick counts of the leukocytes of patients with CGL were abnormally low.
M, TOMONAGA, G, MATSUURA, B, WATANABE, Y, KAMOCHI, N, OZONO   +4 more
openaire   +2 more sources

CSF Cytokine Network Organization Predicts Progression Independent of Relapse and MRI Activity in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno, Matteo Conti, Ettore Dolcetti, Federica Azzolini, Angela Borrelli, Roberta Fantozzi, Mario Stampanoni Bassi, Giovanni Galifi, Giuseppe Maccarrone, Luca Montaguti, Marco Cervigni, Maddalena Dal Pozzo, Roberto Furlan, Annamaria Finardi, Girolama Alessandra Marfia, Marco Salvetti, Antonella Conte, Fabio Buttari, Diego Centonze, Luana Gilio   +19 more
wiley   +1 more source