Results 191 to 200 of about 123,303 (240)

Release of neutrophil proteinase 4(3) and leukocyte elastase during phagocytosis and their interaction with proteinase inhibitors

Scandinavian Journal of Clinical and Laboratory Investigation, 1992
Neutrophil proteinase 4 (NP4) is a major neutral proteinase of the human polymorphonuclear (PMN) leukocyte, which is present in amounts similar to leukocyte elastase.
M Bergenfeldt, K Ohlsson
exaly   +3 more sources

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Kinetics of the inhibition of leukocyte elastase by the bronchial inhibitor

BBA - Proteins and Proteomics, 1982
The rate constant for the association between human leukocyte elastase (EC 3.4.21.11) and human bronchial inhibitor has been determined by competition experiments with alpha 1-proteinase inhibitor. This constant (1.1.10(7) M(-1) . s(-1)) is 6-times lower than that for the association of leukocyte elastase and alpha 1-proteinase inhibitor.
J G Bieth, K Ohlsson, F Gauthier
exaly   +3 more sources

Proteolytic inactivation of human leukocyte elastase

Experientia, 1985
Human leukocyte elastase can be proteolytically inactivated by bovine pancreatic trypsin. Neither porcine pancreatic elastase nor bovine pancreatic chymotrypsin causes inactivation of leukocyte elastase, nor are trypsin, pancreatic elastase, or chymotrypsin themselves susceptible to proteolysis.
R L, Stein, J C, Williams
openaire   +2 more sources

Estimation and characterization of hamster leukocyte elastase

Biochemical Medicine, 1982
Abstract A method is described for the preparation of granule extract from hamster polymorphonuclear leukocytes. The presence of elastase in this extract has been ascertained by the dual criteria of elastin solubilization and synthetic elastase substrate hydrolysis. The extract is also able to cleave one out of three cathepsin-G substrates.
C, Boudier, J G, Bieth
openaire   +2 more sources

Leukocyte Elastase Inhibitor

Annals of the New York Academy of Sciences, 2009
Poly(ADP‐ribose) polymerase‐1 (PARP‐1) uses NAD+ as a substrate to form ADP‐ribose. During apoptosis, caspases cleave PARP‐1 to avoid excessive NAD consumption. Because PARP‐1 is a key regulator of the activity of DNases involved in caspase‐dependent apoptosis, its cleavage is required to promote DNA degradation.
Chloé, Leprêtre, Giuseppina, Sidoli, A Ivana, Scovassi, Alicia, Torriglia   +3 more
openaire   +2 more sources

Polymorphonuclear leukocyte elastase in patients with stroke

Acta Neurologica Scandinavica, 2009
Polymorphonuclear leukocytes (PMNL) are involved in the pathogenesis of acute cerebral ischemia and atherosclerosis. Elastase is one of the proteolytic enzymes released by activated PMNL. We evaluated whether plasma levels of elastase-inhibitor complexes (EIC) are related to acute cerebral damage or with extension of carotid atherosclerosis in patients
N, Vila, M, Elena, R, Deulofeu, A, Chamorro   +3 more
openaire   +2 more sources

Polymorphonuclear leukocyte cells and elastase in tears

Current Eye Research, 1997
To characterize the effects that mode of sampling and overnight eye closure have on the nature of caseinolytic activity recovered in tear fluid.Reflex, open and closed (R, O and C) eye tear fluids were collected by microcapillary tubes or from the inferior formix by Schirmer strip.
M, Sakata, R A, Sack, S, Sathe, B, Holden, A R, Beaton   +4 more
openaire   +2 more sources

Comparison of the Elastolytic Effects of Human Leukocyte Elastase and Porcine Pancreatic Elastase

Biochemical and Biophysical Research Communications, 1976
Porcine and bovine elastins were digested by human leukocyte elastase and porcine pancreatic elastase. The enzymes showed similarities in the extent to which they digested elastin and the pattern and quantitative distribution of N-terminal amino acids in the digests.
R M, Senior, D R, Bielefeld, B C, Starcher   +2 more
openaire   +3 more sources

Inhibition by Boswellic Acids of Human Leukocyte Elastase

The Journal of Pharmacology and Experimental Therapeutics, 1997
Frankincense extracts and boswellic acids, biologically active pentacyclic triterpenes of frankincense, block leukotriene biosynthesis and exert potent anti-inflammatory effects. Screening for additional effects of boswellic acids on further proinflammatory pathways, we observed that acetyl-11-keto-beta-boswellic acid, an established direct, nonredox ...
H, Safayhi, B, Rall, E R, Sailer, H P, Ammon   +3 more
openaire   +2 more sources

The Induction of Pulmonary Emphysema with Human Leukocyte Elastase

American Review of Respiratory Disease, 1977
Abstract Purified human leukocyte elastase was injected into the tracheas of 46 hamsters. Thirteen animals died spontaneously within 1 week, with extensive lung hemorrhage. The elastin content of the lungs was only slightly less than control values 3 hours after injection.
R M, Senior, H, Tegner, C, Kuhn, K, Ohlsson, B C, Starcher, J A, Pierce   +5 more
openaire   +2 more sources