Results 181 to 190 of about 5,749 (201)

Leukotoxin-Diol

American Journal of Respiratory Cell and Molecular Biology, 2001
Leukotoxin is clinically associated with acute respiratory distress syndrome (ARDS). Recently, we found that leukotoxin-diol, the hydrated product of leukotoxin, is more toxic than the parent leukotoxin in vitro (Moghaddam and colleagues, Nature Med. 1997;3:562-566). To test if this difference in the toxicity of leukotoxin and leukotoxin-diol exists in
J, Zheng, C G, Plopper, J, Lakritz, D H, Storms, B D, Hammock   +4 more
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Mannheimia haemolytica leukotoxin

2010
Mannheimia haemolytica is the primary bacterial pathogen of bovine pneumonic pasteurellosis, an economically important disease of cattle worldwide. Leukotoxin (Lkt) produced by M. haemolytica is the major virulence factor of this organism. The cytolytic activity of Lkt is specific for ruminant leukocytes.
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Structure/Function Aspects of Actinobacillus actinomycetemcomitans Leukotoxin

Journal of Periodontology, 1996
Actinobacillus actinomycetemcomitans has been implicated as a causative organism in early‐onset periodontitis. The mechanisms by which A. actinomycetemcomitans is pathogenic are not known, but the organism produces several potential virulence factors, one of which is a leukotoxin.
Edward T, Lally, Irene R, Kieba, Ellis E, Golub, James D, Lear, Jacqueline C, Tanaka   +4 more
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[ARDS and leukotoxin].

Nihon Kyobu Shikkan Gakkai zasshi, 1991
It is well known that pulmonary influx of neutrophils is involved in lung injury in patients with adult respiratory distress syndrome (ARDS). Neutrophils are major contributors to the self-defence mechanism, however, adverse effects of neutrophils have also been recognized. Recently, we found that a highly toxic substance, 9, 10-epoxy-12-octadecenoate (
T, Ozawa, S, Sugiyama, M, Hayakawa, F, Taki   +3 more
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Binding of Pasteurella haemolytica leukotoxin to bovine leukocytes

Infection and Immunity, 1997
Pasteurella haemolytica is the principal bacterial pathogen in the bovine respiratory disease complex. This organism produces an exotoxin (referred to as leukotoxin) during logarithmic-phase growth that is a potent leukocyte-modulating agent. At low concentrations, it activates neutrophils and mononuclear phagocytes to release inflammatory mediators ...
J F, Brown, F, Leite, C J, Czuprynski
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Biological and biochemical characterization of Fusobacterium necrophorum leukotoxin

American Journal of Veterinary Research, 1994
Summary Biological and biochemical characteristics of the leukotoxin of Fusobacterium necrophorum were determined. Culture supernatant of F necrophorum was toxic to polymorphonuclear neutrophilic, leukocytes from cattle and sheep, but not to those from pigs and rabbits.
Z L, Tan, T G, Nagaraja, M M, Chengappa, J S, Smith   +3 more
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Purification of secreted leukotoxin (LtxA) from Actinobacillus actinomycetemcomitans

Protein Expression and Purification, 2002
The RTX (repeats in toxin) family of toxins is important in the pathogenesis of many Gram-negative bacteria. The oral and systemic human pathogen Actinobacillus actinomycetemcomitans produces a member of this family known as leukotoxin (LtxA). Previously, we found that LtxA is secreted into culture supernatants of A. actinomycetemcomitans and that this
Scott C, Kachlany, Daniel H, Fine, David H, Figurski   +2 more
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Electron immunocytochemical localization of Actinobacillus actinomycetemcomitans leukotoxin

Oral Microbiology and Immunology, 1992
The Actinobacillus actinomycetemcomitans leukotoxin was localized in A. actinomycetemcomitans bacteria using an electron immunocytochemical thin‐section labeling method. An immuno‐dot blot procedure was initially used to ascertain the optimal specimen fixation.
P, Berthold, D, Forti, I R, Kieba, J, Rosenbloom, N S, Taichman, E T, Lally   +5 more
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Systemic Aggregatibacter actinomycetemcomitans Leukotoxin‐Neutralizing Antibodies in Periodontitis

Journal of Periodontology, 2017
Background: Leukotoxin (Ltx) expressed by Aggregatibacter actinomycetemcomitans is a powerful exotoxin, which can cause imbalance in host response. Immunoreactivity to Ltx is a marker for presence of leukotoxic A. actinomycetemcomitans, a presence that may modify the disease pattern of colonized individuals.
Pussinen Pirkko J., Sorsa Timo, Pussinen Pirkko J., Sorsa Timo   +3 more
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Cellular Characterization of Leukotoxin Diol-Induced Mitochondrial Dysfunction

Archives of Biochemistry and Biophysics, 2001
Leukotoxin, a cytochrome P450-derived epoxide of linoleic acid, has been implicated as a causative factor in acute respiratory distress syndrome. Conversion of this fatty acid epoxide to leukotoxin diol by epoxide hydrolase has been hypothesized as the critical activation step in leukotoxin-induced cellular toxicity.
M F, Sisemore, J, Zheng, J C, Yang, D A, Thompson, C G, Plopper, G A, Cortopassi, B D, Hammock   +6 more
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