Results 131 to 140 of about 1,986,463 (267)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Adapting Master's-Level Chemistry Education in the United States: Insights from Industry, Academia, and the Literature. [PDF]

J Chem Educ
Johnson B, Lindell A, Goodey NM.
europepmc   +1 more source

Food and health promotion literacy among employees with a low and medium level of education in the Netherlands. [PDF]

BMC Public Health, 2021
Sponselee HCS, Kroeze W, Poelman MP, Renders CM, Ball K, Steenhuis IHM.   +5 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Work challenges and cancer-related cognitive impairment: level of education accounts for unmet needs beyond cognitive impairment severity. [PDF]

Support Care Cancer
Haywood D, Rossell SL, Henneghan A, Baughman FD, Haywood J, Dauer E, Hegde A, Moustafa AA, Hart NH.   +8 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Predictive factors for determining first-attempt success on the American Board of Cardiovascular Perfusion Certification Exams for graduates of a master's level perfusion education program. [PDF]

J Extra Corpor Technol
Palmer AM.
europepmc   +1 more source

Media use in gynecological and obstetric care and women's perceived level of education received of lifestyle-related risks: A cross-sectional study. [PDF]

Womens Health (Lond), 2022
Bombana M, Wensing M, Müller G, Ullrich C, Heinzel-Gutenbrunner M, Wittek M.   +5 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Level of education, labor-market marginalization, and alcohol-related mortality: a cohort study of Swedish men. [PDF]

Eur J Public Health
Thern E, Hemmingsson T, Carlsson E, Kjellberg K, Almroth M.   +4 more
europepmc   +1 more source