Results 81 to 90 of about 1,986,463 (267)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Education Attainment of the Working-Age Population of Moscow According to the Population Census
Здоровье мегаполисаBackground. As a separate constituent entity of the Russian Federation, Moscow is characterized by significant heterogeneity of the population and its determinants of health, largely due to socioeconomic factors, the most important of which is the ...
V. G. Semenova, A. E. Ivanova
doaj +1 more source
The Relationship Between Level of Education, Cognitive Function and Medication Adherence in Patients with Schizophrenia. [PDF]
Neuropsychiatr Dis Treat, 2023 Zhu X, Wen M, He Y, Feng J, Xu X, Liu J.
europepmc +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Culture, Ethnicity, and Level of Education in Alzheimer's Disease. [PDF]
Neurotherapeutics, 2022 Rosselli M +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
EĞİTİM DÜZEYİNİN MEDYA KULLANIMINA ETKİSİ: GAZETE VE TELEVİZYON KARŞILAŞTIRMASI
Sosyal Ekonomik Araştırmalar Dergisi, 2009 Kişilerin sahip olduğu eğitim düzeyi, birçok konuda olduğu gibi medya kullanımında da başat bir etkendir. Kitle iletişim araçlarının vermiş olduğu iletiler, bireyler tarafından anlamlandırılma süreçlerinde, onların almış olduğu eğitimin etkisinde ...
Enderhan Karakoç, Ümit Arklan
doaj