Results 161 to 170 of about 74,070 (251)

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

Personality Functioning and Antisociality of Youth Accessing Residential Substance Use Withdrawal in Australia. [PDF]

Drug Alcohol Rev
Akoka N, Akintola A, Guerin AA, Dunne AL, Daffern M, Bowman H, Bruun A, Cementon E, Chanen A, Coghill D, Lopatecki A, Mullen E, Bedi G.   +12 more
europepmc   +1 more source

Disrupting Helicobacter pylori Iron Homeostasis With Bismuth Nanodrug‐Mediated Nutritional Trap for Targeted Gastric Infection Therapy

Advanced Science, EarlyView.
A “nutritional trap” strategy centered on disrupting bacterial iron homeostasis is proposed. The synthesized Bi‐TP@FU (TBF) can target Helicobacter pylori, interfere with the bacterial iron uptake and utilization processes to disrupt its iron homeostasis, induce bacterial death, and meanwhile preserve the balance of the intestinal flora.
Tianye Fang, Jinzhe Tong, Feng Feng, Cong Liu, Chang Shu, Jiaying Zhu, Shibo Zhang, Shuyue Deng, Wanchao Zuo, Yuhan Song, Jun Yang, Yanmin Ju, Yingying Xing, Jianjun Dai   +13 more
wiley   +1 more source

Personality Pathology and Functional Outcomes During Pharmacological Treatment of Adult ADHD. [PDF]

Personal Ment Health
Jacobsson P, Palage E, Hopwood CJ, Söderpalm B, Krueger RF, Tasselius V, Nilsson T.   +6 more
europepmc   +1 more source

AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing

Advanced Science, EarlyView.
A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li, Haojie Fu, Zhe Wang, Xuanzhou Chen, Ruhong Zhang, Xudong Wang, Louis D. Zhang, Xiang Li, Datao Li   +8 more
wiley   +1 more source

Personality functioning in adolescents with depression: links with childhood maltreatment, psychopathology, self-harm and suicidal ideation. [PDF]

Front Psychiatry
Adler A, Barkauskiene R, Skabeikytė-Norkienė G.   +2 more
europepmc   +1 more source

Hypomethylation of GNA15 Promotes Pancreatic Ductal Adenocarcinoma Progression and Macrophage M2 Polarization via STAT3‐CXCL8 Axis

Advanced Science, EarlyView.
A schematic model summarizing GNA15's mechanism in mediating macrophage M2 polarization and Gemcitabine resistance. ABSTRACT The complexity of pancreatic ductal adenocarcinoma (PDAC) progression, coupled with the lack of effective immunotherapy, underscores the imperative to deepen our understanding of its mechanisms and identify suitable immune ...
Weihui Guo, Zhenyuan Qian, Lei Wang, Weilang Xu, Yuxin Weng, Kai Jiang, Zaiyuan Ye, Ji Xu, Guangyuan Song   +8 more
wiley   +1 more source

Bending‐Stable Pressure Sensor Based on Natural Wood Nanofibers for Ultra‐Low Detection Limit

Advanced Science, EarlyView.
A wood nanofiber‐based flexible pressure sensor with intrinsic bending‐stable performance is developed through a porous electrospun architecture and interdigital electrode design. The device exhibits an ultra‐low detection limit and stable operation under deformation for physiological monitoring and spatial sensing, providing a sustainable strategy for
Xu Zeng, Zhengnan Sun, Yilin Wang, Yao Tan, Ranran Xu, Beomjoon Kim, Juergen Brugger, Xiaosheng Zhang   +7 more
wiley   +1 more source

Lanthanum Carbonate Nanosheets Based Colloidal Hydrogel for Modulating Innate & Adaptive Tumor Immunotherapy by Augmented Cellular Pyroptosis

Advanced Science, EarlyView.
The Gela/decitabine/La2(CO3)3 colloidal (GDLC) hydrogel developed here could reverse the epigenetic silencing of the GSDME gene by the synergistic interaction between DAC and La3+, while concurrently activating caspase‐3, thus facilitating pyroptosis induction under the tumor microenvironment.
Yang Hong, Haitao Wu, Weitao Wang, Xuan Zhang, Qian Chen, Yaoyu Hu, Zhengbao Zha   +6 more
wiley   +1 more source

Personality moderates immunological and functional consequences of caregiver burden. [PDF]

Health Psychol
Brice KN, Argueta DL, Lai VD, Paoletti-Hatcher J, Wu-Chung EL, Zarazúa-Osorio B, Denny BT, Green C, Medina LD, Schulz P, Stinson J, Henry SK, Heijnen C, Fagundes CP.   +13 more
europepmc   +1 more source