Results 181 to 190 of about 11,626,435 (297)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Comparison of BDNF and NGF Levels in Adenomyotic Tissue, Adjacent Myometrium, and Normal Myometrium and Their Correlation with Pain Severity. [PDF]

Int J Womens Health
Heriyanto A, Tjahyadi D, Bayuaji H, Anwar R, Syam HH, Ritonga MA, Halim B, Adlino L.   +7 more
europepmc   +1 more source

Groei van kennis en stagnatie in de Sociologie, Een onkiese beschouwing

, 2011
Levels, M., Niewenhuis, R.
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Sex-related neuropsychiatric recovery from maternal perinatal depression and expression of monoamine and amino acid neurotransmitter levels in specific brain regions of adult offspring. [PDF]

Sci Rep
Czarzasta K, Bogacki-Rychlik W, Joniec-Maciejak I, Machaj E, Momot K, Segiet-Swiecicka A, Sajdel-Sulkowska EM.   +6 more
europepmc   +1 more source

Groei van kennis en stagnatie in de empirisch-theoretische sociologie - een onkiese beschouwing

, 2011
Levels, M., Nieuwenhuis, Rense
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Effects of ABCG2 dysfunction on hyperuricemia progression in premenopausal and postmenopausal women. [PDF]

Hum Cell
Miyoshi Y, Nakayama A, Nakashima H, Hashimoto I, Kawamura Y, Shimizu S, Toyoda Y, Mizuno T, Tanabe R, Hamada Y, Nagayoshi M, Kubo Y, Okada R, Matsunaga T, Yoshioka N, Iwasawa S, Ueno M, Hayano K, Nakaoka H, Yamamoto K, Wakai K, Shinomiya N, Matsuo H.   +22 more
europepmc   +1 more source

Levels of Description and Levels of Reality

Abstract This expository chapter presents a general framework for representing levels and inter-level relations. The framework is intended to capture both epistemic and ontological notions of levels and to clarify the sense in which levels of explanation might or might not be related to a levelled ontology.
openaire   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source