Results 71 to 80 of about 36,908,348 (344)

A multi-level level generator [PDF]

open access: yes2014 IEEE Conference on Computational Intelligence and Games, 2014
Generating content at multiple levels of abstraction simultaneously is an open challenge in procedural content generation. Representing and automatically replicating the style of a human designer is another. This paper addresses both of these challenges through extending a previously devised methodology for pattern-based level generation.
Dahlskog, Steve, Togelius, Julian
openaire   +2 more sources

Gemcitabine, Docetaxel, Melphalan, Carboplatin as Part of Sequential Cycles of High‐Dose Chemotherapy With Autologous Hematopoietic Stem‐Cell Rescue for Multiply Relapsed/Refractory Pediatric Germ Cell Tumors

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Although most malignant germ cell tumors (GCTs) are highly curable with cisplatin‐based therapy, options for patients with multiply relapsed/refractory disease remain limited. For this population, we report the first pediatric use of gemcitabine, docetaxel, melphalan, and carboplatin (GemDMC) as part of sequential cycles of high‐dose ...
Maria Frost   +10 more
wiley   +1 more source

CPX‐351 in High‐Risk Relapsed Pediatric Acute Leukemia: Real‐World Phase 1 Data Establishing the FDA‐Approved Dose

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Outcomes for pediatric relapsed/refractory (R/R) acute myeloid leukemia (AML) remain dismal. CPX‐351, a liposomal formulation of cytarabine and daunorubicin, may have less off‐target toxicities than traditional chemotherapies and has shown improved outcomes for adults with newly diagnosed therapy‐related AML.
Jonathan D. Bender   +17 more
wiley   +1 more source

Incidence and Risk Factors of Serious Osteonecrosis in Pediatric Acute Lymphoblastic Leukemia: A CYP‐C Population‐Based Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Osteonecrosis (ON) is a debilitating complication of acute lymphoblastic leukemia (ALL) therapy. While numerous studies have explored its incidence and associated risk factors, investigations using large‐scale cohorts remain important to characterize ON across heterogeneous populations.
Noémie de Villiers   +5 more
wiley   +1 more source

Naturalizing Information

open access: yesInformation, 2011
Certain definitions of information can be seen to be compatible with each other if their relationships are properly understood as referring to different levels of organization in a subsumptive hierarchy.
Stanley N. Salthe
doaj   +1 more source

Novel Genetic Risk Factor Identified for L‐Asparaginase‐Induced Pancreatitis in Pediatric Patients With Cancer

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background L‐asparaginase is a critical component in treatment protocols for pediatric acute lymphoblastic leukemia. Acute pancreatitis reactions can necessitate delays and, in some cases, discontinuation of L‐asparaginase, which compromises outcomes.
Edward J. Raack   +39 more
wiley   +1 more source

Patient preferences for inflammatory bowel disease treatments: protocol development of a global preference survey using a discrete choice experiment

open access: yesFrontiers in Medicine
BackgroundAs the therapeutic landscape for inflammatory bowel disease (IBD) continues to expand, a need exists to understand how patients perceive and value different attributes associated with their disease as well as with current and emerging ...
Elise Schoefs   +17 more
doaj   +1 more source

Jurisprudential Study of Anti-Religious Virtual Teachings [PDF]

open access: yesInternational Multidisciplinary Journal of Pure Life, 2018
The present study was the jurisprudential answer to the question of whether the Islamic State, during its absence or natural persons, has the legal right to filter web pages, satellite TVs and virtual social networks that seek non-religious or anti ...
Dr. mohammad Mahdi Moheb Al-Rahman (Iran)
doaj   +1 more source

Minimum quality levels and import tariffs [PDF]

open access: yes, 2003
In a vertically differentiated duopoly the use of import tariffs by an importing country decreases domestic welfare if import tariffs are chosen once the firms have made their quality decisions. In this paper we propose import tariffs that are contingent
Hernán, Roberto, Kujal, Praveen
core   +2 more sources

Volanesorsen and Triglyceride Levels in Familial Chylomicronemia Syndrome.

open access: yesNew England Journal of Medicine, 2019
BACKGROUND Familial chylomicronemia syndrome is a rare genetic disorder that is caused by loss of lipoprotein lipase activity and characterized by chylomicronemia and recurrent episodes of pancreatitis. There are no effective therapies.
J. Witztum   +18 more
semanticscholar   +1 more source

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