Results 81 to 90 of about 63,095 (231)

Development of a physiologically‐based pharmacokinetic model for Ritonavir characterizing exposure and drug interaction potential at both acute and steady‐state conditions

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 523-539, March 2025.
Abstract Ritonavir (RTV) is a potent CYP3A inhibitor that is widely used as a pharmacokinetic (PK) enhancer to increase exposure to select protease inhibitors. However, as a strong and complex perpetrator of CYP3A interactions, RTV can also enhance the exposure of other co‐administered CYP3A substrates, potentially causing toxicity.
Lien Thi Ngo, Woojin Jung, Tham Thi Bui, Hwi‐yeol Yun, Jung‐woo Chae, Jeremiah D. Momper   +5 more
wiley   +1 more source

Uma implementação do algoritmo Levenberg-Marquardt dividido para aplicações em visão computacional.

Semina: Ciências Exatas e Tecnológicas, 2009
Em diversas aplicações da visão computacional, é necessário estimar-se, em um modelo, os parâmetros que melhor se ajustam a um conjunto de dados experimentais. Nesses casos, um algoritmo de minimização pode ser utilizado.
José Alexandre de França, Maria Bernadete de Morais França, Marcela Hitomi Koyama, Tiago Polizer da Silva   +3 more
doaj   +1 more source

Engineered Gravel Trench Hyporheic Exchange to Create Cold‐Water Thermal Refuges

River Research and Applications, EarlyView.
ABSTRACT Warming rivers are driving a loss or fragmentation of cold‐water habitat and providing the impetus to develop proactive thermal management approaches to maintain suitable habitat in rivers. One innovative approach is through the creation of cold‐water thermal refuges during periods of thermal stress for aquatic species.
Kathryn A. Smith, Edmund A. Halfyard, Christa Kelleher, Barret L. Kurylyk   +3 more
wiley   +1 more source

Periodic orbits around areostationary points in the Martian gravity field

, 2012
This study investigates the problem of areostationary orbits around Mars in the three-dimensional space. Areostationary orbits are expected to be used to establish a future telecommunication network for the exploration of Mars.
Baoyin, Hexi, Liu, Xiaodong, Ma, Xingrui
core   +1 more source

Spatiotemporal Assessment of Groundwater Interactions With a Regulated River: A Case Study of the Nechako River, Canada

River Research and Applications, EarlyView.
ABSTRACT Regulated rivers represent complex hydrological systems where groundwater–surface water interactions are governed by natural conditions and human interventions. This study investigates the spatiotemporal dynamics of groundwater–surface water exchanges in the Nechako River, British Columbia (Canada), using numerical simulations.
Milad Fakhari, John Gray, Avery Dextrase, Andre St‐Hilaire, Richard Martel   +4 more
wiley   +1 more source

A Novel Approach to Energy Management in Electric Steelworks

steel research international, EarlyView.
Feed‐forward neural networks are exploited to estimate electric energy consumptions of the electric arc furnace and ladle furnace processes. The models are used to optimize production schedule so that more energy intensive grades are produced when the cost of energy is lower.
Valentina Colla, Stefano Dettori, Silvia Cateni, Marco Vannucci, Antonella Vignali, Claudio Mocci, Irene Dovichi, Davide Chionna, Lorenzo Vannini, Enrico Paluzzano, Costanzo Pietrosanti, Davide Onesti, Daniele Venier   +12 more
wiley   +1 more source

Empirical Physics‐Based Normal Behavior Modeling of Drive Train Temperatures With High‐Resolution Wind Turbine Operating Data

Wind Energy, EarlyView.
ABSTRACT The installed wind energy capacity increases every year. However, operation and maintenance costs still make up a considerable portion of the levelized costs of electricity. This costs can be greatly reduced by the application of suitable early fault detection methods. The supervisory control and data acquisition system of wind turbines is one
Timo Lichtenstein, Victor von Maltzahn, Karoline Pelka   +2 more
wiley   +1 more source

Design of artificial neural networks for darcy-forchheimer flow of boger hybrid nanofluid with CattaneoChristov theory: Thermofluidic applications

International Journal of Thermofluids
This study investigates the effects of Marangoni convection on the Darcy-Forchheimer flow of MHD Boger fluid across a sheet using CattaneoChristov heat and mass flux model using artificial neural networks and the Levenberg–Marquardt scheme.
Hussein Ibrahim Hussein, Abdulbasit A. Darem, Asma A. Alhashmi, Nodira Nazarova, Jihad Younis, Munawar Abbas, Hakim AL Garalleh, Amr Alalawi   +7 more
doaj   +1 more source

Artificial Neural Network Surrogate Modelling for Predicting and Optimising CO2 Conversion to Methanol Under Uncertainty

CAAI Transactions on Intelligence Technology, EarlyView.
ABSTRACT This study introduces a data‐driven surrogate modelling framework that combines an artificial neural network (ANN) with particle swarm optimisation (PSO) and a genetic algorithm (GA) to optimise methanol production under uncertain conditions.
Muhammad Zulkefal, Iftikhar Ahmad, Hakan Caliskan, Hiki Hong, Farooq Ahmad   +4 more
wiley   +1 more source

Differentiable Variable Fonts

Computer Graphics Forum, EarlyView.
Abstract Typography is an essential component of visual communication. Editing and animating text appearance for graphic designs, title sequences, commercials, and logos remain highly skilled tasks requiring detailed, hands‐on efforts from pro artists. Automating these challenging manual workflows requires balancing the competing goals of maintaining a
Kinjal Parikh, Danny M. Kaufman, David I.W. Levin, Alec Jacobson   +3 more
wiley   +1 more source