Results 11 to 20 of about 91 (89)
Protein Science, Volume 32, Issue 6, June 2023., 2023 Abstract CTP synthases (CTPS) catalyze the de novo production of CTP using UTP, ATP, and l‐glutamine with the anticancer drug metabolite gemcitabine‐5′‐triphosphate (dF‐dCTP) being one of its most potent nucleotide inhibitors. To delineate the structural origins of this inhibition, we solved the structures of Escherichia coli CTPS (ecCTPS) in complex ...
Matthew J. McLeod +5 more
wiley +1 more source
The Plant Journal, Volume 113, Issue 6, Page 1330-1347, March 2023., 2023 SUMMARY The enzyme glutamine synthetase (EC 6.3.1.2) is mainly responsible for the incorporation of inorganic nitrogen into organic molecules in plants. In the present work, a pine (Pinus pinaster) GS1 (PpGS1b.2) gene was identified, showing a high sequence identity with the GS1b.1 gene previously characterized in conifers.
José Miguel Valderrama‐Martín +5 more
wiley +1 more source
Molecular Oncology, Volume 11, Issue 9, Page 1273-1287, September 2017., 2017 MEK inhibitors suppress ERK‐mediated HER2 Thr701 phosphorylation to enhance clathrin‐dependent HER2/EGFR dimerization and subsequent Akt activation. Targeting the MEK/ERK pathway has been viewed as a promising strategy for cancer therapy. However, MEK inhibition leads to the compensatory PI3K/AKT activation and thus contributes to the desensitization ...
Chia‐Hung Chen +8 more
wiley +1 more source
Growth for Algebras Satisfying Polynomial Identities
International Scholarly Research Notices, Volume 2012, Issue 1, 2012., 2012 The nth codimension cn(A) of a PI algebra A measures how many identities of degree n the algebra A satisfies. Growth for PI algebras is the rate of growth of cn(A) as n goes to infinity. Since in most cases there is no hope in finding nice closed formula for cn(A), we study its asymptotics.
Amitai Regev, E. Aljadeff, F. Marko
wiley +1 more source
Cellular Responses to Cisplatin‐Induced DNA Damage
Journal of Nucleic Acids, Volume 2010, Issue 1, 2010., 2010 Cisplatin is one of the most effective anticancer agents widely used in the treatment of solid tumors. It is generally considered as a cytotoxic drug which kills cancer cells by damaging DNA and inhibiting DNA synthesis. How cells respond to cisplatin‐induced DNA damage plays a critical role in deciding cisplatin sensitivity.
Alakananda Basu +2 more
wiley +1 more source
Structure of rings with certain conditions on zero divisors
International Journal of Mathematics and Mathematical Sciences, Volume 2006, Issue 1, 2006., 2006 Let R be a ring such that every zero divisor x is expressible as a sum of a nilpotent element and a potent element of R : x = a + b, where a is nilpotent, b is potent, and ab = ba. We call such a ring a D*‐ring. We give the structure of periodic D*‐ring, weakly periodic D*‐ring, Artinian D*‐ring, semiperfect D*‐ring, and other classes of D*‐ring.
Hazar Abu-Khuzam, Adil Yaqub
wiley +1 more source
Epidermal Growth Factor Modulates Fetal Thymocyte Growth and Differentiation
Journal of Immunology Research, Volume 5, Issue 3, Page 169-182, 1998., 1997 In the present study, we used the fetal organ culture (FTOC) technique in order to study a putative effect of epidermal growth factor (EGF) on the thymus ontogeny. Functional EGF receptors and more recently the EGF molecule itself, respectively, on the membrane of epithelial components of thymic stroma and on a few thymocytes in adult thymus, had been ...
Claudia S. Freitas +3 more
wiley +1 more source
Radical preservation and the finitistic dimension
Bulletin of the London Mathematical Society, Volume 58, Issue 1, January 2026.Abstract We introduce the notion of radical preservation and prove that a radical‐preserving homomorphism of left artinian rings of finite projective dimension with superfluous kernel reflects the finiteness of the little finitistic, big finitistic, and global dimension.
Odysseas Giatagantzidis
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Glia, Volume 72, Issue 10, Page 1766-1784, October 2024.Main Points Satellite glial cell (SGC) nuclei migrate to the dorsal neuronal soma post‐central branch axotomy. SGC ablation before central branch axotomy enhances neurite regrowth. ErbB inhibition perturbs the SGC injury response and enhances neurite regrowth.
Robin I. Brown +2 more
wiley +1 more source
Filamentation and inhibition of prokaryotic CTP synthase with ligands
mLife, Volume 3, Issue 2, Page 240-250, June 2024.Abstract Cytidine triphosphate synthase (CTPS) plays a pivotal role in the de novo synthesis of cytidine triphosphate (CTP), a fundamental building block for RNA and DNA that is essential for life. CTPS is capable of directly binding to all four nucleotide triphosphates: adenine triphosphate, uridine triphosphate, CTP, and guanidine triphosphate ...
Chenjun Guo, Zixuan Wang, Ji‐Long Liu
wiley +1 more source