Results 191 to 200 of about 12,502 (244)

Levosimendan

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Daniel Tucker, D. Dillon
semanticscholar   +5 more sources

Levosimendan [PDF]

Journal of Pediatric Intensive Care, 2015
We designed this review to examine the mechanism of action of levosimendan (Simdax®, Orion Pharma, Espoo, Finland) and its current clinical application in critically ill adults and children with acutely decompensated severe congestive heart failure and who require inotropic support.
Asher, Levin, Gideon, Paret
openaire   +3 more sources

Efficacy and safety of intermittent intravenous outpatient administration of levosimendan in patients with advanced heart failure: the LION‐HEART multicentre randomised trial [PDF]

European Journal of Heart Failure, 2018
[Abstract] Aims. The LION‐HEART study was a multicentre, double‐blind, randomised, parallel‐group, placebo‐controlled trial evaluating the efficacy and safety of intravenous administration of intermittent doses of levosimendan in outpatients with ...
Maria G Crespo-Leiro, Alessandro Sionis, Domingo Pascual-Figal   +2 more
exaly   +7 more sources

Levosimendan

Drugs, 2001
Levosimendan, a pyridazinone-dinitrile derivative, is a calcium sensitiser with additional action on adenosine triphosphate (ATP)-sensitive potassium channels. It is used intravenously (IV) for the treatment of decompensated cardiac failure. At therapeutic doses, levosimendan exhibits enhanced contractility with no increase in oxygen demands.
D P, Figgitt, P S, Gillies, K L, Goa
  +5 more sources

Levosimendan or Milrinone for Ventricular Septal Defect Repair With Pulmonary Arterial Hypertension.

Journal of Cardiothoracic and Vascular Anesthesia, 2023
OBJECTIVE Both milrinone and levosimendan have been used in patients undergoing surgical closure of ventricular septal defects (VSD) with pulmonary artery hypertension (PAH); however, the evidence base for their use is limited.
Prachi Nag, S. R. Chowdhury, S. K. Behera, Mrinalendu Das, P. Narayan   +4 more
semanticscholar   +1 more source

Preoperative Levosimendan in Patients With Severe Left Ventricular Dysfunction Undergoing Isolated Coronary Artery Bypass Grafting: A Meta-Analysis of Randomized Controlled Trials.

Journal of Cardiothoracic and Vascular Anesthesia, 2023
OBJECTIVE To verify the impact of preoperative levosimendan on patients with severe left ventricular dysfunction (ejection fraction
R. Ayala, D. Gewehr, A. Godoi, C. Velasquez, M. Fernandez, Pedro E. P. Carvalho, Nora Goebel   +6 more
semanticscholar   +1 more source

Levosimendan in Patients with Left Ventricular Dysfunction Undergoing Cardiac Surgery

New England Journal of Medicine, 2017
Sean van Diepen, Stephen E Fremes, A Dave Nagpal   +2 more
exaly   +2 more sources

Levosimendan for Hemodynamic Support after Cardiac Surgery

New England Journal of Medicine, 2017
Giovanni Landoni, Vladimir V Lomivorotov, Antonio Pisano   +2 more
exaly   +2 more sources

Levosimendan Preoperative

Current Pharmaceutical Design, 2013
During the last years an increasing number of patients with high perioperative risk and decreased left ventricular function are referred to cardiac and non-cardiac surgery. In this subgroup of patients, heart failure is the major cause of perioperative morbidity and mortality. In order to prevent and treat this type of complications several therapeutic
Andrea, Rognoni, Alessandro, Lupi, Chiara, Cavallino, Alessia, Veia, Sara, Bacchini, Roberta, Rosso, Gioel Gabrio, Secco, Angelo Sante, Bongo   +7 more
openaire   +2 more sources

Levosimendan Relaxes Thoracic Aortic Smooth Muscle in Mice by Inhibiting PKC and Activating Inwardly Rectifying Potassium Channels

Journal of Cardiovascular Pharmacology, 2023
: Studies have examined the therapeutic effect of levosimendan on cardiovascular diseases such as heart failure, perioperative cardiac surgery, and septic shock, but the specific mechanism in mice remains largely unknown.
Cai-hong Yang, Hui-Qin Qiu, Chan Wang, Ya-ting Tang, Chengming Zhang, Yan-Ying Fan, Xiang-ying Jiao   +6 more
semanticscholar   +1 more source