Results 81 to 90 of about 4,930,458 (259)

Testicular histopathology and its association with germ cell numbers, serum concentrations of reproductive hormones, and semen quality

Andrology, EarlyView.
Abstract Background It is well‐established that spermatogenesis, semen quality, and reproductive hormones are interlinked. It is, however, less well‐described how various specific testicular histopathologies are linked to reproductive hormones and semen quality.
Gülizar Saritas, Nina Mørup, Trine H. Johannsen, Anders Juul, Lise Aksglaede, Sofia B. Winge, Kristian Almstrup   +6 more
wiley   +1 more source

Mullerian-inhibiting substance inhibits rat Leydig cell regeneration after ethylene dimethanesulphonate ablation

, 2011
At the time of publication, Mary Lee and Xiufeng Wu were not yet affiliated with the University of Massachusetts Medical School.The postnatal development of Leydig cell precursors is postulated to be controlled by Sertoli cell secreted factors, which may
Donahoe, Patricia K., Hardy, Matthew P., Salva, Antonio, Wu, Xiufeng, Sottas, Chantal M., MacLaughlin, David T., Lee, Mary M.   +6 more
core   +1 more source

Enniatin B1 induces damage to Leydig cells via inhibition of the Nrf2/HO-1 and JAK/STAT3 signaling pathways

Ecotoxicology and Environmental Safety
Enniatin B1 (ENN B1) is a mycotoxin that can be found in various foods. However, whether ENN B1 is hazardous to the reproductive system is still elusive.
Hongping Shen, Yili Cai, Keqi Zhu, Dong Wang, Rui Yu, Xueqin Chen   +5 more
doaj   +1 more source

The use of deidentified organ donor testes for research

Andrology, EarlyView.
Abstract Our knowledge of testis development and function mainly comes from research using mammalian model organisms, primarily the mouse. However, there are integral differences between men and other mammalian species regarding cellular composition and expression profiles during fetal and post‐natal testis development and in the mature testis ...
Marina V. Pryzhkova, Marnie W. Skinner, Juliana I. Candelaria, Stephen R. Wellard, Philip W. Jordan   +4 more
wiley   +1 more source

Defining the end of puberty in boys: INSL3 and the acute determinants of adult Leydig-cell functional capacity [PDF]

Introduction: Testicular Leydig cells are responsible for producing almost all the testosterone required by men throughout the lifespan, with reduced testosterone (hypogonadism) correlating with age-linked morbidity and mortality.
Tulumcu, Bilal, Ivell, Richard, Anand-Ivell, Ravinder, Alhujaili, Waleed   +3 more
core   +1 more source

The Role of Foxo3 in Leydig Cells

Yonsei Medical Journal, 2015
Foxo3 in female reproduction has been reported to regulate proliferation of granulose cells that form follicles. There are no reports so far that discuss on the role of Foxo3 in males. This study was designed to outline the role of Foxo3 in the testes.Testes from mice at birth to postpartum week (PPW) 5 were isolated and examined for the expression of ...
Choi, Young Suk, Song, Joo Eun, Kong, Byung Soo, Hong, Jae Won, Novelli, Silvia, Lee, Eun Jig   +5 more
openaire   +3 more sources

Semen quality in patients with testicular cancer is associated with age and with greatly elevated levels of beta human chorionic gonadotropin

Andrology, EarlyView.
Abstract Background Poor semen quality is a well‐known feature in patients with testicular germ cell tumours (GCTs) at the time of diagnosis but the underlying biological reasons are incompletely understood. Objectives This study aimed to identify GCT‐specific clinical factors that are involved with poor semen quality in GCT patients.
Klaus‐Peter Dieckmann, Johanna Hochmuth‐Tisch, Andrea Salzbrunn, Cord Matthies, Kathrein von Kopylow, Marta Godlewska, Christian Wülfing, Uwe Pichlmeier, Armin Soave, Christian Guido Ruf   +9 more
wiley   +1 more source

A brief exposure to cadmium impairs Leydig cell regeneration in the adult rat testis

Scientific Reports, 2017
Cadmium is an endocrine disruptor, impairing male reproduction. The objective of this study is to investigate whether cadmium affects rat Leydig cell regeneration and to dissect the underlying mechanism.
Xiaolong Wu, Xiaoling Guo, Huang Wang, Songyi Zhou, Lili Li, Xiaomin Chen, Guimin Wang, Jianpeng Liu, Hong-Shan Ge, Ren-Shan Ge   +9 more
doaj   +1 more source

Identification of MEF2A, MEF2C, and MEF2D interactomes in basal and Fsk‐stimulated mouse MA‐10 Leydig cells

Andrology, EarlyView.
Abstract Background Myocyte enhancer factor 2 transcription factors regulate essential transcriptional programs in various cell types. The activity of myocyte enhancer factor 2 factors is modulated through interactions with cofactors, chromatin remodelers, and other regulatory proteins, which are dependent on cell context and physiological state.
Karine de Mattos, Marie‐Pier Scott‐Boyer, Arnaud Droit, Robert S. Viger, Jacques J. Tremblay   +4 more
wiley   +1 more source

Sertoli cell number defines, and predicts, germ and Leydig cell population sizes in the adult mouse testis [PDF]

, 2017
Sertoli cells regulate differentiation and development of the testis and are essential for maintaining adult testis function. To model the effects of dysregulating Sertoli cell number during development or aging, we have used acute diphtheria toxin ...
Yi Ting Tsai, Ugo Soffientini, Serge Nef, Ana Monteiro, Pitetti, JL, Nef, S, Monteiro, A, Peter J O’Shaughnessy, Handel, Ian, Soffientini, Ugo, O'Shaughnessy, PJ, Jean-Luc Pitetti, Nef, Serge, Rebourcet, Diane, Darbey, Annalucia, Smith, Lee B., Smith, Lee, O'Shaughnessy, Peter J, Soffientini, U, Tsai, YT, Darbey, A, Pitetti, Jean-Luc, Annalucia Darbey, Lee B Smith, Ian Handel, Diane Rebourcet, Smith, LB, Rebourcet, D, Monteiro, Ana, O'Shaughnessy, Peter J., Smith, Lee B, Handel, I, Tsai, Yi Ting   +32 more
core   +1 more source