Results 31 to 40 of about 11,262 (192)

Treatment of malignant leydig cell tumor [PDF]

Cancer, 1991
Malignant Leydig cell tumors (LCT) are rare. Only 32 cases of malignant LCT (as evidenced by metastatic spread) were reported. Generally metastatic spread occurs within 2 years of the primary LCT, and the patient dies within 2 years of the discovery of metastatic disease. The tumor is highly resistant to both radiation and chemotherapy.
K A, Bertram, B, Bratloff, G F, Hodges, H, Davidson   +3 more
openaire   +2 more sources

Evaluation of therapeutic effects of D‐limonene following orchiopexy in the rat model of cryptorchidism

Animal Models and Experimental Medicine, EarlyView.
D‐limonene supplementation enhances testicular recovery following orchiopexy in a rat model of bilateral cryptorchidism. Treatment with D‐limonene reduces oxidative stress (↓MDA, ↑SOD, ↑GPx, ↑TAC), downregulates pro‐apoptotic proteins (↓TNF‐α, ↓BAX, ↓Caspase‐3), and upregulates anti‐apoptotic Bcl‐2 expression.
Arman Norouzi‐Ghalehbala, Mohammadjavad Rezaei‐Varmaziar, Majid Taati, Ali Soleimanzadeh, Abbas Raisi, Farshid Davoodi, Amir Ali Shahbazfar   +6 more
wiley   +1 more source

Ursolic Acid Alleviates Orchitis via Modulating Ferroptosis in Peritubular Myoid Cells of Testis

Animal Research and One Health, EarlyView.
Ursolic acid modulates key ferroptosis‐related pathways in the peritubular myoid cells of the testis in forest musk deer. ABSTRACT Chronic stress adversely affects reproductive health, increasing susceptibility to pathologies such as orchitis. Additionally, the maintenance of iron homeostasis is essential for preserving the function of the testicles ...
Yang Wang, Tianqi Jin, Zexin Chen, Ye Gong, Qimin Liu, Zifang Wu, Heran Cao, Yan Li, Yuyan Liu, Tianhao Yang, Zhihong Jiang, Wuzi Dong   +11 more
wiley   +1 more source

A case report of a patient with a Leydig cell tumor, poor blood pressure control, and ventricular septal hypertrophy

Human Pathology: Case Reports, 2021
Purpose: We report the first case of a testosterone-secreting Leydig cell tumor of the ovary in an elderly female patient with hyperandrogenism, who had poor blood pressure control and a thickened ventricular septum.
Zuoan Qin, Jiangbiao Yu, Ning Guo
doaj   +1 more source

OVARIAN LEYDIG CELL TUMOR

Journal of the ASEAN Federation of Endocrine Societies, 2023
CASEA 41-year-old woman with uterine bleeding and progressive virilization for 5 years was referred to our hospital because of worsening anemia. Abdominal CT and transvaginal ultrasound showed an enlarged uterus and left ovary without any tumor. She underwent abdominal hysterectomy and was diagnosed with leiomyoma then evaluated for virilization ...
Sawika Gitsomboon, Suthinee Kampiwtha, Arnon Poorichitiporn, Pornsawan Wasinghon, Yingyot Chunlakitchawat   +4 more
openaire   +1 more source

Heat stress in spermatogenesis: a redox‐dependent decision network linking ROS, autophagy, and regulated cell death

Biological Reviews, EarlyView.
ABSTRACT Heat stress (HS) is an increasing threat to male reproductive health, disrupting spermatogenesis through complex and interdependent cellular responses within the seminiferous epithelium. Although excessive reactive oxygen species (ROS) production is a hallmark of HS, ROS also act as central regulators of cell fate decisions beyond their role ...
Ribrio Ivan Tavares Pereira Batista
wiley   +1 more source

A Sertoli-Leydig ovarian tumor presenting as ovarian torsion: A case report

Case Reports in Women's Health
Torsion occurs as a complication in 10% of cases of ovarian tumors. It predominantly occurs in benign ones, while malignant tumors are less prone to torsion.
Samia Tligui, Hounaida Mahfoud, Samia Sassi, Hanane Inrhaoun, Najat Lamalmi, Fatima El Hassouni, Samir Bargach   +6 more
doaj   +1 more source

Effects of hypocholesterolemia and chronic hormonal stimulation on sterol and steroid metabolism in a Leydig cell tumor.

Journal of Lipid Research, 1981
The studies presented herein were done to investigate the effects of drug-induced hypocholesterolemia and chronic hormonal stimulation on cholesterol metabolism and steroid biosynthesis in a functional Leydig cell tumor. It was found that 4-aminopyrazolo(
M Ascoli
doaj   +1 more source

A New Paradigm: 46 Structural Cell Types Function as Environment‐Supporting Innate Immune Cells, With Endothelial and Vascular Smooth Muscle Cells as Key Prototypes

iNew Medicine, EarlyView.
ABSTRACT The scope, organization, and biological significance of innate immune functions across structural cell types remain poorly defined. To address these fundamental knowledge gaps, we analyzed experimental data of transcriptomes generated by our group and others.
Juanjuan Liu, Gayani K. Nanayakkara, Yifan Lu, Fatma Saaoud, Keman Xu, Ying Shao, Bo Yuan, Shih‐Yu Hung, Haiyan Xiang, Xianwei Wang, Sadia Mohsin, Sheng Wu, Xiaolei Liu, Juncheng Wei, Zhengjie Zhou, Beata Kosmider, Mingui Fu, Laisel Martinez, Roberto Vazquez‐Padron, Wenhui Hu, Shuping Ge, Hong Wang, Xiaofeng Yang   +22 more
wiley   +1 more source

Proteomic Profiling Using a Proximity Extension Assay Panel on Serum Samples Stored at −25°C Over Several Decades

PROTEOMICS, EarlyView.
ABSTRACT The advent of proteomics assays that provide accurate levels of thousands of proteins from relatively small sample volumes opens possibilities for biomarker research in biobanks with valuable samples. In this study, we leverage the applicability of the Olink proximity extension assay to profile serum samples of the Janus Serum Bank, which have
Steffan Daniel Bos, Sigrún Helga Lund, Renée Turzanski Fortner, Eivind Hovig, Hilde Langseth   +4 more
wiley   +1 more source