Results 211 to 220 of about 12,270 (235)

Luman regulates the activity of the LHCGR promoter

Research in Veterinary Science, 2023
Testosterone in male mammals is mainly secreted by testicular Leydig cells, and its secretion process is regulated by the hypothalamic-pituitary-gonadal axis. After receiving the luteinizing hormone (LH) stimulus signal, the lutropin/choriogonadotropin receptor (LHCGR) on the Leydig cell membrane transfers the signal into the cell and finally increases
Lei, Wang, Qingrui, Meng, Hailun, Wang, Xiaoyu, Huang, Chunchen, Yu, Guangwen, Yin, Dengfeng, Wang, Heji, Jiang, Zhijian, Huang   +8 more
openaire   +2 more sources

A rare cause of primary amenorrhea: LHCGR gene mutations

European Journal of Obstetrics & Gynecology and Reproductive Biology, 2022
The luteinizing hormone/choriogonadotropin receptor (LHCGR) plays a critical role in sexual differentiation and reproductive functions in men and women. Inactivating mutations in this gene lead to Leydig cell hypoplasia (LCH), and cause disorders of sex development (DSD) in patients with 46,XY.
Cayir, Atilla, Karakaya, Amine Aktar, Unal, Edip, Bestas, Asli, Solmaz, Asli Ece, Haspolat, Yusuf Kenan   +5 more
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Variants in DENND1A and LHCGR are associated with endometrioid adenocarcinoma

Gynecologic Oncology, 2012
The aim of this study was to explore the polycystic ovary syndrome (PCOS) related single nucleotide polymorphisms (SNPs) rs13405728 (in gene LHCGR), rs13429458 (in gene THADA) and rs2479106 (in gene DENND1A) in women with endometrial carcinoma.We conducted a case-control study comprising 96 Han Chinese women with endometrial carcinoma, and 192 healthy ...
Zhenyan, Wang, Tao, Li, Wei, Zhang, Li, You, Yueran, Zhao, Mingdi, Xia, Han, Zhao, Zi-Jiang, Chen   +7 more
openaire   +2 more sources

LHCGR Gene Analysis in Girls with Non-Classic Central Precocious Puberty

Experimental and Clinical Endocrinology & Diabetes, 2018
Abstract Background Luteinizing hormone (LH) is a useful parameter in diagnosing precocious puberty. The pubertal response of serum LH to a GnRH stimulation test is varied, and clinical symptoms of precocious puberty are sometimes disproportionate with serum LH concentrations.
Hwal Rim, Jeong, Hae Sang, Lee, Jin Soon, Hwang   +2 more
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Effect of luteinizing hormone/choriogonadotropin receptor (LHCGR) gene on chicken reproductive traits

Molecular Biology Reports, 2013
Luteinizing hormone/choriogonadotropin receptor (LHCGR) gene, potentially related to reproductive traits in chickens, was genotyped by using the Pooled DNA Sequencing, PCR-SSCP and Directing Sequencing techniques. 306 Erlang Mountain chickens form one line (SD03, a line that has been selected for egg quality from a local chicken breed in Sichuan ...
Di Yan, Li, Long, Zhang, Ming Yao, Yang, Huai Liang, Xu, Hua Dong, Yin, Ying, Li, Qing, Zhu   +6 more
openaire   +2 more sources

Mechanism underlying the stimulation by IGF-1 of LHCGR expression in porcine granulosa cells

Theriogenology, 2021
IGF-1 plays important roles in mammalian fertility by promoting cell growth and increasing steroid hormone secretion. Although IGF-1 significantly upregulated luteinizing hormone/choriogonadotropin receptor (LHCGR) gene expression in granulosa cells in a previous study, the mechanism was unclear. The present experiment was designed to primarily explore
Ying, Han, Yanhong, Chen, Feng, Yang, Xiaomei, Sun, Shenming, Zeng   +4 more
openaire   +2 more sources

Mapping of the luteinizing hormone/choriogonadotropin receptor gene (LHCGR) to chicken chromosome 3 [PDF]

Animal Genetics, 2001
Source/description: The chicken luteinizing hormone/choriogonadotropin receptor gene has been cloned and sequenced. To produce markers for linkage mapping genomic DNA sequence from exon 7 to exon 9 including the intervening introns and exon was cloned and sequenced (EMBL accession number AJ289775).
Ge, SF, Romanov, MN, Sharp, PJ, Burt, DW, Paton, IR, Dunn, IC   +5 more
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Associations of FSHR and LHCGR gene variants with ovarian reserve and clinical pregnancy rates

Reproductive BioMedicine Online, 2021
Are there any associations between the variants of FSHR c.2039 G>A (p. Ser680Asn, rs6166) and LHCGR c.935A>G (p. Asn312Ser, rs2293275) and ovarian reserve, ovarian response, clinical pregnancy rate and POSEIDON group?A total of 210 infertile women were enrolled in this prospective study. The gene variants were analysed by the Sanger method.
Chun, Guo, Hui, Yu, Guimei, Feng, Qun, Lv, Xiaoqi, Liu, Xiangqin, Liu   +5 more
openaire   +2 more sources

miRNA-592 is downregulated and may target LHCGR in polycystic ovary syndrome patients

Reproductive Biology, 2015
The polycystic ovary syndrome (PCOS) is an endocrine disorder mainly associated with infertility. Abnormal regulation of relevant genes is required for follicular development in PCOS. In the current study, the expression of serum miRNAs of PCOS patients was explored using miRNA array followed by qRT-PCR assays.
Jin, Song, Shan, Luo, Shang-Wei, Li
openaire   +2 more sources