Cortical Somatostatin Neurons Regulate Seizure Susceptibility via MINAR1/Gαs–cAMP Signaling
Advanced Science, EarlyView.Our study identifies MINAR1 as a novel regulator of cortical interneuron excitability and seizure susceptibility. MINAR1 is preferentially expressed in SST+ interneurons. Genetic ablation of MINAR1 leads to seizure hypersensitivity, reduced SST+ neuron excitability, and impaired Gαs–cAMP signaling, disrupting the E/I balance.
Wei‐Tang Liu +20 more
wiley +1 more source
INTERNATIONAL INVESTMENT POSITION OF THE REPUBLIC OF MOLDOVA [PDF]
Economica, 2020 Investment activity in the Republic of Moldova is the most important factor that determines the socio-economic development of the country. Attracting foreign direct investments remains a current task, the effective solution of which depends on the ...
Rodica BURBULEA +2 more
doaj
Corporate Pension Policy and the Value of PBGC Insurance [PDF]
This paper derives the value of PBGC pension insurance under two scenarios of interest. The first allows for voluntary plan termination, which appears to be legal under current statutes.
Alan J. Marcus
core
Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma
Advanced Science, EarlyView.Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian +7 more
wiley +1 more source
Population Aging and Fiscal Policy in Europe and the United States [PDF]
In this paper, we compare the total size of intertemporal public liabilities (IPLs) of several European countries and the United States. We utilize the machinery of generational accounting in order to calculate the composition of the countries IPLs, that
Bernd Raffelhüschen, Jagadeesh Gokhale
core
A generic model for spouse's pensions with a view towards the calculation of liabilities
, 2015 We introduce a generic model for spouse's pensions. The generic model allows for the modeling of various types of spouse's pensions with payments commencing at the death of the insured.
Sokol, Alexander
core +1 more source
A Metal‐Free Carbon Monoxide Prodrug Suppresses Metastasis of Pancreatic and Breast Cancer
Advanced Science, EarlyView.A metal‐free carbon monoxide (CO) prodrug, CO‐116, delivers controlled systemic CO without inhalation. CO suppresses the HRG1–heme axis, reducing intracellular heme availability. Attenuation of this pathway inhibits metastatic progression in pancreatic and triple‐negative breast cancer models.
Tiantian Zhang +15 more
wiley +1 more source
LIABILITY TO SUPPLIERS REPORTING STANDARDIZATION - QUALITY GROWTH FACTOR OF ACCOUNT INFORMATION [PDF]
Annals of the University of Oradea: Economic Science, 2010 Under no.11 position paper "Economic and Monetary Union", Romania took responsibility of reporting according to European System of Accounts - ESA 95. Public Institution classification is necessary to delineate the perimeter of general government (S.13 ...
Ivan Raluca +2 more
doaj
Controlling Claims and Liabilities and its Use for Identification of Bankruptcy /
GeoScience Engineering, 2011 Článek se zabývá controllingem pohledávek a závazků, objasňuje jeho pojmy a principy využívané v praxi. Vysvětluje také, jak lze v podniku pohledávky monitorovat dle časového hlediska a také dle vybraných ukazatelů finanční analýzy.
Sternadelová Michaela
doaj +1 more source
Liabilities in private law [PDF]
, 2008 This article elaborates upon and defends the distinction between “primary duty” claims and “primary liability” claims in private law introduced in a previous article. In particular, I discuss the relevance of the distinction to the debates over fault and
Jaffey, P
core +1 more source