Results 271 to 280 of about 124,422 (334)

A Randomized Trial of Encorafenib and Cetuximab Versus Irinotecan/Cetuximab or FOLFIRI/Cetuximab in Chinese Patients With BRAFV600E Mutant Metastatic Colorectal Cancer: The NAUTICAL Study

Cancer Medicine, Volume 15, Issue 3, March 2026.
ABSTRACT Background Colorectal cancer (CRC) is a major health burden globally and in China, where 3%–5% of cases involve the BRAFV600E mutation, which is associated with aggressive disease and therefore a poor prognosis. Although the combination of encorafenib and cetuximab has demonstrated improved survival in BRAFV600E mutant metastatic CRC (mCRC ...
Wang Xicheng, Deng Yanhong, Zhang Yanqiao, Liu Tianshu, Yuan Xianglin, Yang Jianwei, Zhang Tao, Zang Aimin, Liu Yu, Huang Li, Ye Feng, Zong Hong, Ba Yi, Klauck Isabelle, Vedovato Jean‐Claude, Groc Mélanie, Guo Angela, Li Jian, Shen Lin   +18 more
wiley   +1 more source

Nanoplatform-Enhanced Photodynamic Therapy in Head and Neck Squamous Cell Carcinoma: Advances and Future Directions. [PDF]

Int Dent J
Zhang W, Gan M, He Y, Ma W, Liu S, Liu D.   +5 more
europepmc   +1 more source

When Fever Defies Diagnosis: Wissler–Fanconi Syndrome as an Atypical Presentation of Adult‐Onset Still's Disease

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Adult‐onset Still's disease should be considered in young adults presenting with fever of unknown origin and inflammatory arthritis, even in the absence of rash or sore throat. Recognition of the Wissler–Fanconi variant and early ferritin testing can prevent diagnostic delay and enable prompt, effective immunosuppressive therapy.
Attaina Najeeb, Kamran Taj, Aqsa Abdul Qader, Salar Sultan, Khadija Waleed, Rahmat Gul Omarzai   +5 more
wiley   +1 more source

Geographic Variation in Morphology and Physiology of <i>Meretrix meretrix</i> (Linnaeus, 1758) Along the Chinese Coast. [PDF]

Animals (Basel)
Bao J, Zhu Y, Liu L, Han S, Wang F, Hu H, Zhang X, Li L, Jiang M.   +8 more
europepmc   +1 more source

ShenQi DiHuang Decoction (SQDHD) Ameliorates Neuroinflammation and Neuropsychiatric Manifestations in Pristane Induced Lupus Mice via Blocking JAK1‐STAT3 Pathway

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
SQDHD exerts neuroprotective effects and alleviates behavioral deficits in PIL mice, likely by inhibiting the JAK1‐STAT3 pathway in activated CVECs. These findings underscore the therapeutic potential of SQDHD and establish it as a promising candidate for the treatment of NPSLE.
Jie Chen, Chumiao Cui, Fei Xu, Jiayan Feng, Jingyu Chen, Xueru Wang, Hui Yuan, Chenye Jin, Yutian Li, Yang Yun   +9 more
wiley   +1 more source

Expression and clinical significance of growth differentiation factor-15 in vascular cognitive impairment based on bioinformatic analysis. [PDF]

J Transl Int Med
Lin J, Mao N, Wu Z, Yang R, Zhang Y, Ge Y.   +5 more
europepmc   +1 more source

Ferroptosis‐Driven Neuronal Damage Exacerbation in Diabetic Stroke: Implications of SLC7A11 Inhibition

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
The current study uncovered aggravated cerebral ischemic injury and neurological dysfunction following diabetic stroke, in which ferroptosis was involved. SLC7A11 expression was inhibited in the early stages of reperfusion during diabetic stroke, and both ferroptosis inhibitors and neuron‐specific enforced expression of SLC7A11 mitigated neuronal lipid
Siyuan Liu, Min Liu, Binbin Wang, Miao Sun, Huikai Yang, Mengyao Qu, Libin Ma, Likai Shi, Yuxiang Song, Peng Li, Lulu Zhou, Wugang Hou, Weidong Mi, Yulong Ma   +13 more
wiley   +1 more source

Decapping scavenger enzyme as a promising biomarker in diabetic foot ulcers: A need for cautious interpretation. [PDF]

World J Diabetes
Huang XL, Wang Y, Chen DF, Duan JN, Michael N, Jiang R, Ge YS, Wang B.   +7 more
europepmc   +1 more source

ALKBH3 suppresses ischemia/reperfusion‐induced PANoptosis by regulating the ZBED6/STAT1/AIM2 axis through m1A demethylation

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
ALKBH3 alleviates myocardial ischemia/reperfusion injury by suppressing PANoptosis. ALKBH3 promotes ZBED6 translation via mRNA m1A demethylation. ZBED6 promotes the interaction between STAT1 and NEDD4L to facilitate STAT1 ubiquitination and subsequent degradation.
Hongtao Diao, Chunlei Wang, Yuting Xiong, Qiaoyue Zhao, Xinyue Zhang, Xiaohui Qi, Yuan Zou, Jiaxuan Li, Linghua Zeng, Wei Si, Feng Zhang, Ping Pang, Ning Wang, Yu Bian, Baofeng Yang   +14 more
wiley   +1 more source