Results 171 to 180 of about 2,167,425 (344)

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

The association of arterial partial oxygen pressure with mortality in patients with severe acute pancreatitis: a retrospective cohort study. [PDF]

Intensive Care Med Exp
Chen Y, Wan J, Shu W, Yang X, Ke H, He W, Zhu Y, Lu N, Xia L.   +8 more
europepmc   +1 more source

Glymphatic Dysfunction Reflects Post‐Concussion Symptoms: Changes Within 1 Month and After 3 Months

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mild traumatic brain injury (mTBI) may alter glymphatic function; however, its progression and variability remain obscure. This study examined glymphatic function following mTBI within 1 month and after 3 months post‐injury to determine whether variations in glymphatic function are associated with post‐traumatic symptom severity ...
Eunkyung Kim, Han Gil Seo, Roh‐Eul Yoo, Byung‐Mo Oh   +3 more
wiley   +1 more source

Transfusion-related adverse events in patients with restrictive or liberal transfusion strategy. An analysis of the MINT trial. [PDF]

Transfusion
Ghafghazi S, Uhl L, Herbert B, Bertolet M, Alexander JH, Goodman SG, Raval J, Roubille F, Fordyce CB, Goldfarb M, Bainey K, de Andrade PB, Senaratne J, Bracey A, Roswell RO, Lopes R, Simon T, Steg G, Brooks MM, Hebert PC, Carson JL, Triulizi DJ, MINT Trial Investigators.   +22 more
europepmc   +1 more source

Evaluation of the Efficacy and Safety of Satralizumab in a Pregnant NMOSD Patient With AQP4/MOG‐IgG Dual Seropositive: A Case Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Neuromyelitis Optica Spectrum Disorder (NMOSD) is a chronic autoimmune neuroinflammatory disease, typically characterized by antibodies against aquaporin 4 (AQP4‐IgG) or myelin oligodendrocyte glycoprotein (MOG‐IgG). Simultaneous seropositivity for both antibodies in a single patient is exceedingly rare.
Yeting Luo, Shuhua Xie, Xianghong Liu
wiley   +1 more source

Liberal versus restrictive transfusion strategies in patients with acute brain injury: a systematic review and meta-analysis of randomized controlled trials. [PDF]

Proc (Bayl Univ Med Cent)
M Manasrah A, Alayidh M, A Ibrahim A, A Maiz A, Rifai M, Alayidh S, Al Asheikh SA, Alaklah A, Rakab MS, Turkmani M, Abuelazm M.   +10 more
europepmc   +1 more source

Life‐Threatening Bradycardia in Anti‐NMDA‐Receptor Encephalitis and a Novel Use for Permanent Pacing

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Pediatric anti‐NMDA receptor encephalitis (pNMDARE) is an autoantibody‐mediated disorder that can cause severe autonomic dysfunction, including symptomatic bradycardia and asystole. Dysautonomia can last for years, making it very challenging to manage.
Sarah Tucker, Abhijit Das, Andres Jimenez, Areeba Basit, Yike Jiang, Emily A. Smitherman, Heather Van Mater, Taylor Howard, Alexander J. Sandweiss, Kristen S. Fisher   +9 more
wiley   +1 more source

Letter to the editor regarding 'Liberal or restrictive transfusion for veno-arterial extracorporeal membrane oxygenation patients: a target trial emulation using the OBLEX study data'. [PDF]

Crit Care
van der Meer TA, Raasveld SJ, Müller MCA, Vlaar APJ, Schenk J.   +4 more
europepmc   +1 more source

An Out‐of‐Place Etiology: Recognizing FMR1 Premutation in the Memory Clinic

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The FMR1 gene premutation (55–200 CGG repeats) is usually associated with a wide range of symptoms and phenotypes within the Fragile X‐tremor/ataxia syndrome (FXTAS), but may also manifest as predominant or isolated cognitive decline. We describe three male patients referred for progressive cognitive impairment and behavioral changes. Standard
Guido Greco, Caterina Motta, Enrica Marchionni, Maria Rosaria D'Apice, Carlangelo Carrese, Giuseppe Novelli, Alessandro Martorana, Chiara Giuseppina Bonomi   +7 more
wiley   +1 more source

Changes in firearm intentions and behaviors after the 2024 United States presidential election. [PDF]

Inj Epidemiol
Anestis MD, Bond AE, Burke KC, Altikriti S, Semenza DC.   +4 more
europepmc   +1 more source