Results 211 to 220 of about 1,923,934 (309)

Transfusion-related adverse events in patients with restrictive or liberal transfusion strategy. An analysis of the MINT trial. [PDF]

Transfusion
Ghafghazi S, Uhl L, Herbert B, Bertolet M, Alexander JH, Goodman SG, Raval J, Roubille F, Fordyce CB, Goldfarb M, Bainey K, de Andrade PB, Senaratne J, Bracey A, Roswell RO, Lopes R, Simon T, Steg G, Brooks MM, Hebert PC, Carson JL, Triulizi DJ, MINT Trial Investigators.   +22 more
europepmc   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

A critical appraisal tool for interdisciplinary study designs: Conceptual grounding and application in healthy ageing research. [PDF]

MethodsX
Piriu AA, Bufali MV, Cappellaro G, Compagni A, Torbica A.   +4 more
europepmc   +1 more source

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

The association of arterial partial oxygen pressure with mortality in patients with severe acute pancreatitis: a retrospective cohort study. [PDF]

Intensive Care Med Exp
Chen Y, Wan J, Shu W, Yang X, Ke H, He W, Zhu Y, Lu N, Xia L.   +8 more
europepmc   +1 more source

Liberal versus restrictive transfusion strategies in patients with acute brain injury: a systematic review and meta-analysis of randomized controlled trials. [PDF]

Proc (Bayl Univ Med Cent)
M Manasrah A, Alayidh M, A Ibrahim A, A Maiz A, Rifai M, Alayidh S, Al Asheikh SA, Alaklah A, Rakab MS, Turkmani M, Abuelazm M.   +10 more
europepmc   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Contextualising abortion opinions in Kenya: A vignette-based national survey. [PDF]

PLOS Glob Public Health
Ushie BA, Akuku IG, Mutuku E, Juma K.
europepmc   +1 more source