Results 181 to 190 of about 291,260 (355)

The six phases of prolonged veno-venous extracorporeal membrane oxygenator support: a conceptual framework. [PDF]

Crit Care
Hoffman KR, Diehl A, Nixon P, Yong SA, Fan E, Hodgson C, Burrell AJC.   +6 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Correction: Effects of exercise regimens on balance ability in older patients with osteoporosis: a systematic review and Bayesian network meta-analysis of randomized controlled trials. [PDF]

Front Physiol
Liu X, Chang M, Yuan H, Zheng X, Tian W, Li D, Liao D, Cui L.   +7 more
europepmc   +1 more source

Mozambique Liberation Front (FRELIMO). Communique no. 130 (1968 July 3)

, 1968
Mozambique Liberation Front (FRELIMO). Communique no. 130 reports on the provinces of Tete, Eastern Niassa and Western Niassa: FRELIMO guerrilla made several arrests, ambushes, mined several roads, attacked camps, and in a combined action of several ...
Mozambique Liberation Front (FRELIMO)
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

John Chilembwe’s Praxis

African Theological Journal for Church and Society
This study discusses the phenomenon of John Chilembwe’s praxis as a harbinger for the construction of public theology in Malawi. It articulates an apocalyptic, soteriological, ecclesiological, and missional vision in which the church is understood as a ...
Jones Hamburu Mawerenga
doaj  

Retrospective Study on Liberation in Dogs Undergoing Mechanical Ventilation for Longer Than 24 Hours. [PDF]

J Vet Emerg Crit Care (San Antonio)
McNally AE, Greensmith TD, Cortellini S.
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Correction: Elevated IL-17A level is associated with poor overall survival following immune checkpoint inhibitors combined with targeted therapy in hepatocellular carcinoma with hyperbilirubinemia. [PDF]

Front Immunol
Wang J, Pan S, Xiong C, Tian J, Wang Y, Yu Y, Wang S, Shen Y, Yang L, Liu X, Luan J, Jia M, Duan X, Wang F, Meng F.   +14 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source