Results 261 to 270 of about 291,260 (355)

De-escalation of critical care and prevention of iatrogenicity through a self-tracking daily rounding checklist. [PDF]

Front Pediatr
Fashina OA, Kahoud RJ, Crow SS, Arteaga GM, Kawai Y.   +4 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Correction: The role of TGF-β1 in chronic multilobar segmental bronchial stenosis and advances in targeted drug research. [PDF]

Front Pharmacol
Wu M, Yang Q, Xie Y, Hou Y, Xue Q.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Intergenerational hypertension transmission before and after South Africa's democratic transition. [PDF]

SSM Popul Health
Avogo WA.
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Comment on 'the impact of body mass index on the efficacy of CDK4/6 inhibitors in patients with metastatic breast cancer'. [PDF]

Ann Med
Chen X, Gu S, Ding S.
europepmc   +1 more source

How Can the Sedative and Analgesic Effects of Virtual Reality Technology Be More Precisely Assessed in Pediatric Dental Care? Methodological Insights From an Ongoing Randomized Controlled Trial [Response to Letter]. [PDF]

J Pain Res
Cao W, Liu C, Yang Z, Wang Y, Dou J, Qiu X, Zhang L, Lv A, Tang L.   +8 more
europepmc   +1 more source

Multidisciplinary introduction of peritoneal dialysis enabling ICU liberation and home-based care in Ebstein's anomaly with refractory ascites and CKD: a case report. [PDF]

CEN Case Rep
Funahashi Y, Fukui S, Kato N, Kosugi T, Mizuno M, Maruyama S.   +5 more
europepmc   +1 more source

A Critical Appraisal of Pyrolysis Pretreatment in Lithium-Ion Battery Recycling: From High-Temperature Material Transformations to Environmental Impact. [PDF]

ChemSusChem
Saeed M, Klemettinen L, Klemettinen A, Serna-Guerrero R.   +3 more
europepmc   +1 more source