Results 21 to 30 of about 8,965 (260)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Data librarianship as a field study

Transinformação, 2020
Data are generated during all human activities related to digital technology. In recent times, scientific research has increasingly opted for digital data as its primary source of data; data definition changes for different disciplines and researchers ...
Alexandre Ribas SEMELER, Adilson Luiz PINTO   +1 more
doaj   +1 more source

Factors Influencing the Choice of Librarianship as a Career Among Students in Tanzania

International Journal of Librarianship, 2022
This study examined factors influencing the choice of librarianship as a career among students in Tanzania. A quantitative research approach, the descriptive survey study design, was adopted for this study. Data was collected using online questionnaires.
Martin Kanyika
doaj   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

A Survey On Tehran University Of Medical Sciences Students’ Familiarity With Personal Information Management

پیاورد سلامت, 2014
Background and Aim: Personal Information Management (PIM) is a novel approach comprising three interactive parts of information resources, dimensions, and tools.
Shahram Sedghi, Masoud Rudbari, Nida Abdollahi, Leila Abdollahi, Maryam Haseli, Maryam Zarghani   +5 more
doaj   +2 more sources

When does the librarianship became a science in Russia?

Библиосфера, 2016
The main article objective is a terminological analysis of «librarianship» concept. The development of theoretical concepts of librarianship as a science and as a branch of knowledge is explored.
A. N. Vaneev
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Information therapy (infotherapy): An experimental Study to prepare remedial program based on information to reduce the severity of some psychological problems among orphans at Orphanages in Alexandria

Cybrarians Journal, 2017
The purpose of the study is to study the Information therapy (Ix) Subject and shed light on what it is in the field of libraries; and to determine the role of Librarians and information professionals in the Information Therapy Process; and to verify the
Rowan Abd El- Hameed
doaj   +1 more source