Results 101 to 110 of about 277,055 (308)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Funding Dilemma in Pakistani Libraries: Causes, Effects, Responses

, 2006
Literature on funding problems of Pakistani libraries reveals that poor economy of the country, inflation, low priority to education and price increase of library material are the main causes of this dilemma.
Hameed, Abdul, Mahmood, Khalid, Haider, Syed Jalaluddin   +2 more
core  

Mobile Wellness Resources

, 2016
Stress in medical students is not unheard of, nor is it unexpected. Medical students have rigorous schedules and must pass a series of examinations, placing enormous pressure on them to succeed.
Herron, Jennifer
core   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Competition of the German MLA (AGMB) "Pioneer projects in medical libraries" 2018: introduction of the winners

, 2018
The projects of the winners of the competition "Pioneer projects in medical libraries" 2018 are introduced and the statement of the jury explained.Die Projekte der Preisträger des Wettbewerbes "Leuchtturmprojekte an Medizinbibliotheken" 2018 werden ...
Reimann, I
core   +1 more source

Evaluation of Education Hospital Libraries in Mazandaran and Babol University of Medical Sciences according to Standards of Hospital Libraries

مدیریت اطلاعات سلامت, 2014
Introduction: Progress in medical technology requires medical libraries to promote based on the references standards. The aim of this study was to evaluate the status of hospital libraries of Mazandaran and Babol University of medical sciences, on the ...
Nasrin Ebrahim Ghuchi, Farideh Rostami, Ahmad Najafi   +2 more
doaj  

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

German MLA (AGMB) competition "Pioneer projects in medical libraries" 2021 - announcement

, 2020
The competition "Pioneer projects in medical libraries" 2021 is announced.Der Wettbewerb "Leuchtturmprojekte an Medizinbibliotheken" wird für 2021 erneut ...
Reimann, I
core   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source