Results 91 to 100 of about 5,035,698 (371)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

open access: yesFEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Survey of Web Developers in Academic Libraries [PDF]

open access: yes, 2008
A survey was sent to library web designers from randomly selected institutions to determine the background, tools, and methods used by those designers. Results, grouped by Carnegie Classification type, indicated that larger schools were not necessarily ...
Connell, Ruth S
core   +2 more sources

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

open access: yesFEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig   +7 more
wiley   +1 more source

Studying the Quality of Analytic Cataloging and Classification of Arabic Books in National Library & Archives of IR of Iran during 2001-2007 [PDF]

open access: yesتحقیقات اطلاع‌رسانی و کتابخانه‌های عمومی, 2010
Purpose: The present research has been carried out with the purpose of studying the analytic cataloging and classification (library of congress) of Arabic books in National Library & Archives of IR of Iran during 2001-2007.
Mostafa Mahfoozi   +2 more
doaj  

Same query - different results? A study of repeat queries in search sessions [PDF]

open access: yes, 2011
Typically, three main query reformulation types in sessions are considered: generalization, specication, and drift. We show that given the full context of user interactions, repeat queries represent an important reformulation type which should also be ...
Jones, Gareth J.F., Leveling, Johannes
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Establishing a resource center: A guide for organizations supporting community foundations [PDF]

open access: yes, 2003
Maintaining a resource center such as a library is a central tasks of an association to serve its members, though one of the first to be neglected. WINGS-CF commissioned this guide to assist organizations supporting community foundations to review and ...
Barbara Denemark Long
core  

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

open access: yesFEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava   +3 more
wiley   +1 more source

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