Results 71 to 80 of about 5,452 (259)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

The janus kinase 2 (JAK2) mutation: A review of its role in polycythaemia vera and other myeloproliferative disorders

Sahel Medical Journal, 2011
Background: Unlike Chronic Myeloid Leukemia (CML) whose genetic basis (the Philadelphia chromosome), has become a household name, that of Polycythaemia Vera and other non-leukemic myeloproliferative diseases has not equally received wide publicity.
M U Nwagu
doaj  

Teknik Üniversite Kütüphaneleri: Karadeniz Teknik Üniversitesi, Faik Ahmet Barutçu Kütüphanesi Örneği / Technical University Libraries, An Example: Karadeniz Technical University Faik Ahmet Barutçu Library [PDF]

Bilgi Dünyası, 2008
[Turkish abstract]Ülkemizde, geçmişleri 1950’li yıllara dayanan teknik üniversitelerimizin ve teknik bilginin önemini belirten bu çalışmada, Karadeniz Teknik Üniversitesi, Faik Ahmet Barutçu Kütüphanesi tanıtılmakta; Kütüphane’nin kullanıcılara sunduğu ...
Beyhan Karpuz
doaj  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Gender difference as the risk of diabetic foot ulcers in T2DM patients: a meta-analysis [PDF]

Journal of Men's Health
To investigate the gender difference as a risk factor of diabetic foot ulcer (DFU) in diabetes mellitus type 2 (T2DM) patients. The online databases including China National Knowledge Infrastructure (CNKI), Wanfang, China Biomedical Literature, PubMed,
Xiaogang Hu, Runfang Kang, Ling Chen, Xiaopeng Hu   +3 more
doaj   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Hemşirelik Alanında Güçlü Bir Bilgi Merkezi: Koç Üniversitesi HemşirelikYüksek Okulu Kütüphanesi / A Developed Information Center in Nursing: Library of the Koç University School of Nursing [PDF]

Bilgi Dünyası, 2007
ÖzBu makalede, Koç Üniversitesi Hemşirelik Yüksek Okulu Kütüphanesi’nin kuruluşu, koleksiyon yapısı, sunulan hizmetler ve Türkiye’de hemşireliğin profesyonel gelişimi için kurulmuş bir branş kütüphanesi olarak öneminden bahsedilecektir.
Güssün Güneş
doaj  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source