Results 51 to 60 of about 25,190,607 (340)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Landmark Report (Vol. 4, no. 9) [PDF]
, 1984 Newsletter published by the Landmark Association; this local group advocates the preservation, protection and maintenance of architectural, cultural and archaeological resources in Bowling Green and Warren County ...
Kentucky Library Research Collections,
core +5 more sources
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Unethical research trend: shadow libraries [PDF]
Sao Paulo Medical Journal, 2018 Research articles spread knowledge that has been shaped by scientific communities. Access to this literature is essential for any scholar. Evidently,“biblio gifts” are easily accessible online without any charge from text-sharing platforms. Similarly, virtual groups in social networking websites such as Facebook, LinkedIn, Twitter and virtual blogs are
Asim, Zeeshan, Sorooshian, Shahryar
openaire +5 more sources
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Heritage Science, 2021 The Huexotzinco Codex is one of the earliest surviving manuscripts from the early colonial period of Mexico. The codex pertains to the legal case of conquistador Hernán Cortés and contains paintings and documents detailing the seizure of Cortés’ personal
Tana Elizabeth Villafana +2 more
doaj +1 more source
Landmark Report (Vol. 2, no. 8) [PDF]
, 1982 Newsletter published by the Landmark Association; this local group advocates the preservation, protection and maintenance of architectural, cultural and archaeological resources in Bowling Green and Warren County ...
Kentucky Library Research Collections,
core +2 more sources
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source