Results 141 to 150 of about 3,998,759 (349)
Eastern Librarian, 2012 The main objective of this paper is to explore the changes in library education in the context of the emergence of both information science and knowledge management. This paper is based on the review of scientific literature published in books, journals, websites, and other secondary sources and on the authors own viewpoints.
openaire +3 more sources
Molecular Oncology, EarlyView.Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu +11 more
wiley +1 more source
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
Концепции медиареальности как теоретико-методологическая основа библиотековедческой реальности
Библиосфера, 2010 Problems of mediareality in the field of library science are considered. The notion «reality» as a general theoretical basis for the study of library activity is analyzed. The notion of «library science reality» is revealed.
doaj
The National Reference Library of Science and Invention [PDF]
, 1961 J. Farradane
openalex +1 more source
Molecular Oncology, EarlyView.Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma +9 more
wiley +1 more source
Об объекте и предмете библиотековедческих исследований
Библиосфера, 2010 The authors treat different approaches to the definition of object and subject in library science investigations, offer their own definition of the notion «the object of library science investigation» as a library process and come to the conclusion, that
doaj
Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
A Variational Beam Model for Failure of Cellular and Truss‐Based Architected Materials
Advanced Engineering Materials, EarlyView., 2023 Herein, a versatile and efficient beam modeling framework is developed to predict the nonlinear response and failure of cellular, truss‐based, and woven architected materials. It enables the exploration of their design space and the optimization of their mechanical behavior in the nonlinear regime. A variational formulation of a beam model is presented
Konstantinos Karapiperis +3 more
wiley +1 more source