Results 151 to 160 of about 224,322 (265)

RHINO: An Integrative Multi‐Omics Framework Linking Circadian Physiology to Precision Medicine

Advanced Science, EarlyView.
RHINO (RHythmic Interacting Network for multi‐Omics) is an integrative framework that maps circadian regulation across diverse genetic and disease contexts and prioritizes druggable circadian targets. Released as an AI‐powered interactive web portal, RHINO unifies genetic, regulatory, disease, and drug–target information, enabling context‐specific ...
Ying Chen, Chengxuan Chen, Dishu Zhou, Panpan Liu, Roberto E. López‐Valiente, Yuan Liu, Cam Mong La, Isabella Beraldo Xavier, Sean M. Hartig, Pradip Saha, Zheng Sun, Leng Han, Dongyin Guan   +12 more
wiley   +1 more source

Biomimetic Gradient Hydrogels Regulate Osteochondral Regeneration Microenvironment Remodeling via Spatiotemporal Programming Engineering

Advanced Science, EarlyView.
Electric field‑driven continuous gradient hydrogel GHZF4 achieves spatiotemporal growth factor release, modulates immune microenvironment, angiogenesis and osteochondral differentiation. It realizes cell‑free functional osteochondral repair in rat/rabbit models, offering a promising biomimetic strategy for gradient tissue regeneration.
Xiaolian Niu, Shengzhao Xiao, Di Huang, Xuesong Wang, Yanwei Cao, Xiaodan Sun, Nicholas Dunne, Xiaoming Li   +7 more
wiley   +1 more source

Unraveling Bone‐Skin Crosstalk Enables miRNA Nanoformulation for Cutaneous Neurovascular Reconstruction in Diabetic Mice

Advanced Science, EarlyView.
This study unravels that bone fracture accelerates diabetic wound healing by releasing exosomal microRNA (miR‐130b‐3p). To mimic this bone‐skin crosstalk, we engineered a self‐assembling agomir‐130b‐3p nanocomplex. Delivered via a photocrosslinkable hydrogel, this bio‐inspired therapy provides sustained localized agomir release.
Tao Shen, Hongdou Shen, Weiyue Wu, Zhuoying Jiang, Bin Liu, Yansi Xian, Rui Peng, An Yan, Yu Ben, Yong Shi, Xiang Chen, Baosheng Guo, Qing Jiang, Weijun Wang, Pingqiang Cai   +14 more
wiley   +1 more source

Multiscale Coupling From Mastication to Retronasal Aroma Perception: The PG‐DTCFN Model and Multiphysics Simulation

Advanced Science, EarlyView.
Using grilled lamb skewers as a model system, this work builds a multiscale coupling framework from oral processing to retronasal aroma perception, reveals dual‐kinetic release patterns and Electroencephalogram‐characterized central encoding features, and proposes an interpretable physics‐guided deep learning model validated by multiphysics simulation,
Che Shen, Xiongfeng He, Zihao Li, Zidong Chen, Jiajin Sun, Xinyu Jiang, Yunhui Zhang, Lizhang Wu, Ran Wang, Jingnan Lu, Bo Wang, Kezhou Cai, Baocai Xu   +12 more
wiley   +1 more source

Intermittent Fasting Restores Cardiac Lipid Homeostasis in Diabetic Cardiomyopathy in Association With Akkermansia Muciniphila and 1‐methyl‐L‐histidine

Advanced Science, EarlyView.
Intermittent fasting reshapes the gut microbiota in diabetic cardiomyopathy, restoring Akkermansia muciniphila and the microbiota‐associated metabolite 1‐methyl‐L‐histidine. This shift is linked to improved cardiac lipid homeostasis, reduced lipid peroxidation, and attenuated myocardial injury, highlighting a gut microbiota–metabolite–lipid axis in ...
Kaiyuan Jiang, Fen Xiong, Yiwen Peng, Lingfei Meng, Xinran Wang, Yingruo Xu, Tian Tang, Hongchang Gao   +7 more
wiley   +1 more source

The personality of library service.

Bulletin of the Medical Library Association, 2006
openaire   +2 more sources

Automation and Active Learning for the Multi‐Objective Optimization of Antibody Formulations

Advanced Science, EarlyView.
Successful antibody formulation necessitates balancing factors such as thermal stability, colloidal stability, and viscosity across a vast excipient design space. This work integrates robotic liquid handling, high‐throughput biophysical characterization, and multi‐objective Bayesian optimization in an iterative closed‐loop Design‐Build‐Test‐Learn cycle.
D. Christopher Radford, Matthew Tamasi, Elena Di Mare, Adam J. Gormley   +3 more
wiley   +1 more source

Perceived benefits and constraints of artificial intelligence integration in teachers' college libraries: a TAM-based study. [PDF]

Front Artif Intell
Chibidi I, Magwa L.
europepmc   +1 more source

Programmable Nanobody‐Targeting Chimeras Enable Intracellular Viral Protein Degradation

Advanced Science, EarlyView.
Nab‐TAC enables targeted degradation of HBV surface antigen (HBsAg) in vivo. By fusing nanobody‐based recognition domains with programmable proteasome‐recruiting degradation signals, Nab‐TAC reduces HBsAg levels in a hydrodynamic HBV mouse model. ABSTRACT Chronic hepatitis B virus (HBV) infection remains a major global health challenge, largely because
Max Yu‐Chen Pan, Ting‐Hui Lee, Tzu‐Ning Peng, Eva Yi‐Hsuan Wu, Yu‐Ting Chiu, Chih‐Chien Chiu, Hong Vinh Nguyen, Yuan‐Shao Pao, Ming‐Hong Chao, Richard Kuan‐Lin Lee, Han‐Chung Wu, Lily Hui‐Ching Wang   +11 more
wiley   +1 more source

A Large Scale Multi‐Modal Workflow for Battery Characterization: From Concept to Implementation

Advanced Energy Materials, EarlyView.
Isolated characterization techniques produce independent datasets and single‐property insights. However, progressively more holistic interpretations of battery‐material behavior is needed in the future. Here we demonstrate a coordinated multimodal workflow enabling the correlation of heterogeneous datasets and the construction of multidimensional ...
François Cadiou, Cinthya Herrera, Duncan Atkins, Elixabete Ayerbe, Giorgio Baraldi, Stéphanie Belin, Anass Benayad, Didier Blanchard, Federico Capone, Ennio Capria, Isidora Cekic‐Laskovic, Robert Dominko, Kristina Edström, Ajay Gautam, Lukas Helfen, Antonella Iadecola, Quentin Jacquet, Gregor Kapun, Xinyu Li, Aleksandar Matic, Nataliia Mozhzhukhina, Andrew J. Naylor, Poul Norby, Chris O'Keefe, Alexandre Ponrouch, Jean‐Pascal Rueff, Elena Tchernykova, Deyana Tchitchekova, Israel Temprano, Nikita Vostrov, Marnix Wagemaker, Martin Winter, Christian Wölke, Tejs Vegge, Sandrine Lyonnard   +34 more
wiley   +1 more source