Results 91 to 100 of about 4,573,689 (264)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

LES ATTEINTES AU DROIT A L’INFORMATION A LA SUITE DES COUPURES INTEMPESTIVES D’INTERNET EN REPUBLIQUE DEMOCRATIQUE DU CONGO

open access: yesKAS African Law Study Library, 2019
La réflexion sur le droit d’accès à l’information par l’internet en République Démocratique du Congo a montré que ce droit n’est pas, en réalité, un nouveau droit.
Jean Jacques Kahunga Mapela
doaj   +1 more source

Justify or die? - using contingent valuation of service provision in a UK public library [PDF]

open access: yes, 2006
The public library service in the UK is currently under pressure to justify its existence. An Audit Commission report suggested that if current borrowing rates for libraries continue into the future, libraries would be effectively issuing no books by ...
McGettigan, L.   +2 more
core  

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

open access: yesFEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan   +6 more
wiley   +1 more source

User Attitudes on E-Books Collection in Mahatma Gandhi University Library: A Case Study [PDF]

open access: yes, 2012
A study on the user’s attitudes, interest and understanding of e-book collections. The sample taken for the study is the E-book collection developed at the Mahatma Gandhi University Library and its users.
Jasimudeen, S.   +2 more
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

A study of bronchial asthma in Malta [PDF]

open access: yes, 1969
This paper was read at the 12th Annual Clinical Meeting of the British Medical Association in Malta. The incidence of bronchial asthma in Malta is not well documented.
Fenech, Frederick F.
core  

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

open access: yesFEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava   +3 more
wiley   +1 more source

Safety in Numbers: Developing a Shared Analytics Services for Academic Libraries [PDF]

open access: yes, 2015
Purpose It is clear that libraries consider the use of data to inform decision making a top priority in the next five years. Jisc’s considerable work on activity data has highlighted the lack of tools and services for libraries to exploit this data.
Showers, Ben, Stone, Graham
core  

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