Results 61 to 70 of about 848,646 (256)

Overview Biological License Application

International Journal of Advanced Research in Science, Communication and Technology
Biological products are highly evolving products its respects years. Thus biological products needs to be regulated. In USA biological products are approved and regulated by food and drug administration (FDA). To get approval of biologicals in USA, biologics license application is used BLA ensures that safe and effective products are approved in the ...
null Sarthak Bhausaheb Nidhane, null Sanket Vijay Vidhate, null Pooja Bhausaheb Kolse   +2 more
openaire   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

CATEGORIZATION OF EVENT SEQUENCES FOR LICENSE APPLICATION [PDF]

, 2005
The purposes of this analysis are: (1) Categorize (as Category 1, Category 2, or Beyond Category 2) internal event sequences that may occur before permanent closure of the repository at Yucca Mountain. (2) Categorize external event sequences that may occur before permanent closure of the repository at Yucca Mountain.
Ragan, G.E., Mecheret, P., Dexheimer, D.
openaire   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Indonesian License Plate Detection and Recognition System using Gaussian YOLOv7

Jurnal Ilmu Komputer dan Informasi
In recent years, Automatic License Plate Recognition (ALPR) systems have garnered attention in computer vision research. However, practical applications face challenges such as inconsistent lighting, diverse license plate designs, and environmental ...
Juan Thomas Wijaya, Aniati Murni Arymurthy   +1 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A Robust License Plate Detection System Using Smart Device

JOIV: International Journal on Informatics Visualization
The license plate recognition (LPR) system is widely employed in various applications. However, most research studies have used a fixed camera rather than a moving one.
Muhammad Darwish Bin Mohamad Azhar, Kah Ong Michael Goh, Law Check Yee, Tee Connie   +3 more
doaj   +1 more source

The Role of Real-World Evidence in FDA-Approved New Drug and Biologics License Applications. [PDF]

Clin Pharmacol Ther, 2022
Purpura CA, Garry EM, Honig N, Case A, Rassen JA.   +4 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Development of a Nigeria Vehicle License Plate Detection System

Applications of Modelling and Simulation, 2019
The importance of license plate detection system cannot be overemphasized in intelligent transport systems. License plate is a major component in most of the applications related to intelligent transport system.
I. B. Oluchi, A. E. Adewale, M. B. Mua’zu, O. N. Salefu, P. O. Oyibo   +4 more
doaj