Results 21 to 30 of about 55 (46)

Cannabidiol Lacks Direct Effect on Cortical Excitability: A Randomized, Double Blind, Placebo Controlled, 3‐Way Crossover Trial

open access: yesClinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 147-157, January 2026.
Cannabidiol (CBD) is approved as an adjunctive treatment of seizures associated with Dravet syndrome, Lennox–Gastaut Syndrome, and tuberous sclerosis. Its therapeutic and adverse effects are thought to arise, at least partly, from a pharmacokinetic interaction with clobazam, another anti‐seizure medication (ASM).
Andriy A. Gorbenko   +7 more
wiley   +1 more source

Changes in the cortical GABAergic inhibitory system with ageing and ageing‐related neurodegenerative diseases

open access: yesThe Journal of Physiology, Volume 604, Issue 2, Page 689-706, 15 January 2026.
Abstract figure legend With ageing and age‐related neurodegenerative diseases, the amount of GABA and GABAergic inhibition as well as the modulation (indicated by sine wave) of GABAergic inhibition is reduced, whereas excitation is increased. In many parts of the brain, this leads to a mismatch of facilitatory (green neurons) and inhibitory (red ...
Wolfgang Taube, Benedikt Lauber
wiley   +1 more source

MXenes: Emerging Materials for Environmental Biochemical Sensing Platforms

open access: yesElectron, Volume 3, Issue 4, November 2025.
MXenes (e.g., transition metal carbides, nitrides, and carbonitrides), among those potential candidates for sensing materials, show promising potential with their intrinsically two‐dimensional large interactive area, wide‐range‐tunable material properties, active surface chemistry, and excellent processability for large‐scale fabrication.
Min Gao   +10 more
wiley   +1 more source

Predicative Possession in Ukrainian and Intra‐Slavonic Language Contact1

open access: yesTransactions of the Philological Society, Volume 123, Issue 3, Page 428-459, November 2025.
Abstract Ukrainian has two inherited syntactic forms for possessive have: a transitive one with a lexical have‐verb, and an intransitive, originally locative be‐construction. On the basis of four corpus studies, the article establishes their relative frequency in Middle Ukrainian writing (17th and 18th c.), Modern Ukrainian dialects (20th c.), and ...
Jan Fellerer
wiley   +1 more source

Breeze of Continuity: New Evidence for the Occupation of Jumeirah Throughout the Islamic Period

open access: yesArabian Archaeology and Epigraphy, Volume 36, Issue 1, Page 306-327, November 2025.
ABSTRACT The Jumeirah Archaeological Research Project seeks to reassess the long‐term occupation of Jumeirah through an integrated study of three key archaeological sites—Jumeirah 1, 2 and 3. This study builds upon previous excavations and archival data to refine the chronology of the settlement and examine whether these sites functioned as a single ...
Karol Juchniewicz   +4 more
wiley   +1 more source

Enhanced response inhibition in patients with drug‐resistant juvenile myoclonic epilepsy: Event‐related potentials evidence of excitatory–inhibitory imbalance

open access: yesEpilepsia Open, Volume 10, Issue 5, Page 1532-1544, October 2025.
Abstract Objective To investigate the excitatory–inhibitory imbalance in drug‐resistant Juvenile Myoclonic Epilepsy (DR‐JME) patients using event‐related potentials during motor and cognitive tasks. Methods Eighteen JME patients and 11 healthy controls performed a visual Go No‐Go task while sitting (single‐task) and walking (dual‐task).
Leviashvilli Sarah   +5 more
wiley   +1 more source

Corticomotor Responses to Experimental, Acute, and Chronic Lower Limb Pain: A Systematic Review and Meta‐Analysis

open access: yesBrain and Behavior, Volume 15, Issue 9, September 2025.
Motor threshold varied by region and diagnosis. We also observed consistent shifts in the corticomotor representations of painful lower limb muscles. Differences in map volume between experimental and clinical pain may suggest temporal variation in corticomotor responses.
Simon J. Summers   +7 more
wiley   +1 more source

Investigating the Modulation of Corticomotor and Neuromuscular Function by Contralateral and Ipsilateral Experimental Pain Applied During Cycling

open access: yesScandinavian Journal of Medicine &Science in Sports, Volume 35, Issue 9, September 2025.
ABSTRACT Pain can impair exercise performance, but its influence on motor control, in particular the effect of robust experimental pain on the timecourse of corticomotor responses throughout prolonged, exhaustive cycling, remains unclear. We tested the hypothesis that an augmented experimental pain intervention applied to exercising and non‐exercising ...
Jenny Zhang   +5 more
wiley   +1 more source

Effects of a Single Session 400 Hz Transcranial Pulsed Current Stimulation on Corticospinal and Corticocortical Excitability and Hand Dexterity: A Double‐Blind RCT

open access: yesPsychophysiology, Volume 62, Issue 7, July 2025.
ABSTRACT The effects of 400 Hz anodal and cathodal transcranial pulsed current stimulation of the primary motor cortex (400 Hz a‐tPCSM1, 400 Hz c‐tPCSM1) on corticospinal excitability (CSE) and corticocortical excitability (CCE) and hand dexterity remain underexplored.
Shapour Jaberzadeh   +3 more
wiley   +1 more source
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