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شبیه‌سازی رواناب سطحی شهری و اولویت‌بندی روش‌های توسعه‌کم‌اثر با استفاده از مدل SWMM (مطالعه موردی: شهر نیشابور) [PDF]

open access: yesمدیریت آب و آبیاری
اخیرا تغییر خصوصیات هیدرولوژیک و پاسخ حوضه شهری نسبت به بارش و سیلاب‌ها از نظر کمی و کیفی در زندگی بشر و منابع مشهودتر شده است. جلوگیری از اتلاف این هرزآب‌ها و به تبع آن جبران کمبود منابع‌آبی،‌ گامی موثر در این خصوص است.
اسماعیل حصاری   +2 more
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

A randomized crossover study of the effect of butorphanol–lidocaine and tramadol–lidocaine on sevoflurane's minimum alveolar concentration in dogs

open access: yesFrontiers in Veterinary Science, 2023
Inhalational anesthesia is routinely used in small animal surgery. Selecting a suitable drug combination is vital since it may negatively affect the patient's physiological condition.
Mohamed Marzok   +9 more
doaj   +1 more source

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang   +10 more
wiley   +1 more source

Integrating Participatory Approaches in Research: Power, Dilemmas and Potentials

open access: yesDiaconia, 2021
This article introduces and discusses participatory approaches in research as an epistemological and methodological contribution to research in general and more specifically to diaconal research. I outline characteristics of
Inger Marie Lid
doaj   +1 more source

Clinical Practice Guideline for Evaluation and Management of Peripheral Nervous System Manifestations in Sjögren's Disease

open access: yesArthritis Care &Research, EarlyView.
Objective Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and autonomic nervous system neuropathies.
Anahita Deboo   +88 more
wiley   +1 more source

Chondroid Syringoma: A Rare Lower Lid Tumor

open access: yesDelhi Journal of Ophthalmology
Chondroid syringoma is a very rare primary skin tumor that accounts for just 0.01%–0.1% of all skin malignancies. Although it is highly common in the head-and-neck region, eyelid involvement is extremely unusual.
Rajwinder Kaur   +3 more
doaj   +1 more source

Dieta de murciélagos filostómidos del valle de Kosñipata, San Pedro, Cusco - Perú

open access: yesRevista Peruana de Biología, 2012
En el presente estudio se evaluó la dieta de murciélagos filostómidos de los bosques montanos del valle de Kosñipata (San Pedro, Cusco). Las especies evaluadas pertenecieron a los géneros Carollia, Sturnira y Anoura.
Rossana Maguiña   +2 more
doaj   +1 more source

Cracking the Code: Which Ocular Symptoms Predict Dry Eye Signs? Insights from a large international sicca registry

open access: yesArthritis Care &Research, Accepted Article.
Purpose The study aimed to identify symptom‐based predictors of dry eye disease (DED) signs in the Sjögrens International Collaborative Clinical Alliance (SICCA) cohort. Methods Retrospective analysis examining 16 ocular symptoms (most graded 0‐4) and artificial tear (AT) use (graded 0‐3) as predictors of DED signs [abnormal ocular surface staining ...
Pragnya R Donthineni   +7 more
wiley   +1 more source

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