Results 91 to 100 of about 148,325 (342)
Angewandte Chemie International Edition, Accepted Article.This review explores the potential of mechanochemistry in the late‐stage modification of active pharmaceutical ingredients (APIs), offering a comprehensive analysis of methods designed to transform structurally complex molecular scaffolds. By examining the scope, efficiency, and mechanistic aspects of these approaches, the review highlights protocols ...
Johanna Templ, Lars Borchardt
wiley +1 more source
Advances in Metal‐Free Transamidation: A Sustainable Approach to Amide Bond Formation
Chemistry – An Asian Journal, EarlyView.This review highlights the recent developments of transamidation reactions under metal‐free reaction conditions. Various amines including weak nucleophilic amines such as aromatic amines have been used to achieve the transamidation reactions under mild and relatively green reaction conditions. Abstract The amide functionalities are a crucial functional
Niharan Sivaraj +2 more
wiley +1 more source
Innovative transdermal drug delivery systems: Benefits, challenges, and emerging application
BMEMat, EarlyView.The graphical abstract illustrates the diverse nanostructures employed in transdermal drug delivery systems, highlighting their unique mechanisms to penetrate the intricate layers of skin. It provides a detailed representation of the skin's complex anatomy, emphasizing the challenges posed by its barrier properties.
Syed Waqas Ali Shah +9 more
wiley +1 more source
Time Course of the Soleus M Response and H Reflex after Lidocaine Tibial Nerve Block in the Rat
The Scientific World Journal, 2013 Aims. In spastic subjects, lidocaine is often used to induce a block predictive of the result provided by subsequent surgery. Lidocaine has been demonstrated to inhibit the Hoffmann (H) reflex to a greater extent than the direct motor (M) response ...
Kévin Buffenoir +2 more
doaj +1 more source
Anesthesia for cystotomy in a dog with pancreatitis and a portosystemic shunt [PDF]
, 2010 A 21-month-old Cocker spaniel with a portosystemic shunt, a moderate thrombocytopenia and a history of pancreatitis, was anesthetized for a cystotomy to remove bladder polyps and stones.
Brearley, JC +3 more
core +1 more source
Management of post‐implant fibrous dysplasia in the maxilla: A case study
Clinical Advances in Periodontics, EarlyView.Abstract Background Fibrous dysplasia is generally rare, and even rarer in older adults. Special care is needed when altering the alveolar bone in these cases, especially if an implant is involved. This case study highlights such a scenario. Methods This case study details the experience of a 63‐year‐old African American female who presented with a ...
Yousef Taha Y. Amrou +4 more
wiley +1 more source
Egyptian Journal of Anaesthesia, 2018 Background: To study the efficacy of systemic lidocaine in suppressing toll-like receptor 4 (TLR4) protein level in BALB/c mouse with sterile injury.
Robert Hotman Sirait +5 more
doaj
Respiratory Research, 2018 Background Endobronchial administration of lidocaine is commonly used for cough suppression during diagnostic bronchoscopy. Recently, nebulization of lidocaine during bronchoscopies under deep sedation with fiberoptic intubation using a distinct spray ...
Tobias Müller +2 more
doaj +1 more source
Crestal approach for repair of oroantral bone defects and subsequent implant placement
Clinical Advances in Periodontics, EarlyView.Abstract Background Oroantral communication (OAC) can occur after a dental extraction. Occasionally, bony defects may persist despite successful soft tissue closure of the OAC. The absence of bone in these areas poses challenges for dental implant placement.
Min Yang +3 more
wiley +1 more source
Mass spectrometry in ocular drug research
Mass Spectrometry Reviews, EarlyView., 2023 Abstract Mass spectrometry (MS) has been proven as an excellent tool in ocular drug research allowing analyzes from small samples and low concentrations. This review begins with a short introduction to eye physiology and ocular pharmacokinetics and the relevance of advancing ophthalmic treatments.
Eva M. del Amo +6 more
wiley +1 more source