Engineering Hybrid Extracellular Vesicles for Functional mRNA Delivery
This study optimizes two methods for the generation of extracellular vesicle (EV)‐mimetic‐Lipid Nanoparticle (LNP) (CELLNPs) and EV‐LNP (HEVs) hybrid nanoparticles for messenger (mRNA) delivery. The authors screen lipid compositions to maximize hybrid nanoparticle formation and analyze the resulting nanoparticles with single particle characterization ...
Ana Filipa Louro +6 more
wiley +1 more source
ER stress upregulates S100A11 in steatohepatitis models via epigenetic modifications within the lipotoxicity-influenced enhancer. [PDF]
Daniel PV +12 more
europepmc +1 more source
σ-modified Lie Group Generalized-α Methods for Constrained Multibody Systems
Stefan Holzinger +2 more
openalex +1 more source
Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen +30 more
wiley +1 more source
Symplectic physics-embedded learning via Lie groups Hamiltonian formulation for serial manipulator dynamics prediction. [PDF]
Wang F, Chen L, Ding J.
europepmc +1 more source
Charge carrier concentration and mobility in TiO2, ZrO2, and HfO2 powder films are experimentally mapped as a function of temperature. The results uncover polaron‐mediated transport regimes and field‐activated conduction, enabling the design of oxide‐based electronic and energy devices with thermally tunable functionality.
Beatriz Moura Gomes +3 more
wiley +1 more source
The Hierarchical Structure of Sheep Wool and Its Impact on Physical Properties
Sheep wool, a prevalent α‐keratinous fiber, is an essential model for studying protein‐based fibers. Its genetic diversity across breeds enables the establishment of multiscale structure‐property relationships, uncovering previously elusive insights into wool's hierarchical structure.
Serafina R. France Tribe +9 more
wiley +1 more source
The impact of shared sense of agency and moral dispositions on intergroup dishonesty. [PDF]
Piperno G +3 more
europepmc +1 more source
Harmonic Morphisms and Minimal Conformal Foliations on Lie Groups [PDF]
Sigmundur Gudmundsson, Thomas Jack Munn
openalex +1 more source

