PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao +16 more
wiley +1 more source
Machine learning-based model for predicting contralateral central lymph node metastasis in papillary thyroid carcinoma with isthmus proximity. [PDF]
Wang L, Han Y, Wang C, Sun Z, Zhang H.
europepmc +1 more source
Robotic Materials With Bioinspired Microstructures for High Sensitivity and Fast Actuation
In the review paper, design rationale and approaches for bioinspired sensors and actuators in robotics applications are presented. These bioinspired microstructure strategies implemented in both can improve the performance in several ways. Also, recent ideas and innovations that embed robotic materials with logic and computation with it are part of the
Sakshi Sakshi +4 more
wiley +1 more source
Characterizing Sleep Disturbance Subgroups and Identifying Associated Factors in Traditional Chinese Medicine Nurses: A Latent Profile Analysis and Explainable Machine Learning Approach. [PDF]
Liu C +5 more
europepmc +1 more source
A Review on Biodegradable Materials of Sustainable Soft Robotics and Electronics
Biodegradable materials are gaining increasing attention in soft robotics and electronics due to their environmental friendliness, showing great potential for sustainability. In this review, the classification of biodegradable materials, their applications in the field of soft robotics and electronics, as well as the challenges and future prospects ...
Yizhu Xie +8 more
wiley +1 more source
Cardiac CT in the era of artificial intelligence: precision imaging, treatment guidance and optimised risk stratification for coronary artery disease. [PDF]
Zhong Z +6 more
europepmc +1 more source
The Disordered Region of ASXL1 Acts as an Auto‐Regulator Through Condensation
ASXL1's long IDR encodes an electrostatic “basic platform + acidic brake” that autoregulates condensation. Truncation at a clinical hotspot lifts this brake, forming condensates that retarget BRD2, remodel local chromatin accessibility, and impair neutrophil maturation.
Xiao Fang, Qiwei Li, Wenqing Zhang
wiley +1 more source
Beyond Euclid: an illustrated guide to modern machine learning with geometric, topological, and algebraic structures. [PDF]
Papillon M +10 more
europepmc +1 more source
Navigating the Ethereal Tightrope: The Nanogenerator Manipulates Neurons for Immune Equilibrium
This review explores how nanogenerators modulate neuroimmune responses, offering innovative strategies for treating neurological disorders. By interfacing with neural pathways, they enable precise control of immune activity, especially via vagus nerve stimulation.
Jia Du +5 more
wiley +1 more source

