Results 41 to 50 of about 61,050 (267)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Journal of New Theory, 2017 Abstaract−In this paper we introduce the concept of fuzzy Lie ideal and anti fuzzy Lie ideal by using a t-norm T and a t-conorm C, respectively. Next we introduce the concept of quotient fuzzy Lie ideal with respect to t-norm T. We investigate some their
Rasul Rasuli
doaj
Intermediate rings of complex-valued continuous functions
Applied General Topology, 2021 For a completely regular Hausdorff topological space X, let C(X, C) be the ring of complex-valued continuous functions on X, let C ∗ (X, C) be its subring of bounded functions, and let Σ(X, C) denote the collection of all the rings that lie between C ...
Amrita Acharyya +3 more
doaj +1 more source
Higher Derivations on Lie Ideals
TEMA - Tendências em Matemática Aplicada e Computacional, 2002 Summary: We present a brief proof of a recently proved result [\textit{M. Ferrero} and \textit{C. Haetinger}, Quaest. Math. 25, No. 2, 249-257 (2002; Zbl 1009.16036), Corollary 1.4]. The main result states that if \(R\) is a prime ring of characteristic different from 2 and \(U\) is a Lie ideal of \(R\) where \(U\not\subset Z(R)\), the center of \(R\),
openaire +4 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
The McCance Brain Care Score and Mortality: Evidence From a Large‐Scale Population‐Based Cohort
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives This study aimed to examine the relationship between the McCance Brain Care Score (BCS) and mortality in the general population. Methods We conducted a prospective, population‐based cohort study using data from the UK Biobank. Participants with complete data enabling calculation of BCS and full mortality information were included ...
Zhiqiang Xu, Xiaoxiao Wang, Nan Li
wiley +1 more source
Primary ideals of Lie algebras
, 2021 Let L be a not necessarily finite dimensional Lie algebra. The popular concepts of prime and primary ideals in ring theory were introduced in Lie algebras by \textit{N. Kawamoto} [Hiroshima Math. J. 4, 679--684 (1974; Zbl 0303.17008)] and \textit{F. Aldosray} [The ideal and subideal structure of Lie algebras. University of Warwick (PhD Thesis) (1984)].
Ashour, Arwa +2 more
openaire +1 more source
Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang +10 more
wiley +1 more source
Arthritis Care &Research, Accepted Article.Background Clinical response to Mycophenolic acid (MPA) is highly heterogeneous; thus, therapeutic drug monitoring (TDM) may help improve treatment efficacy. This systematic review and meta‐analysis examined therapeutic ranges for MPA levels associated with better outcomes and safety in patients with SLE, particularly those with extra‐renal ...
Zahraa Qamhieh +5 more
wiley +1 more source