Results 111 to 120 of about 1,930,714 (341)

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Synergistic Effects of Lignocellulosic Baglog Compost and Biochar on Tomato Plant Growth

BioResources
Indonesian agriculture faces multifaceted challenges, particularly the need to enhance productivity while maintaining environmental sustainability to ensure high-quality food production.
Titin Handayani, Septi Syahrani, Ira Nurhayati Djarot, Agusta Samodra Putra, Netty Widyastuti, Akhmad Rifai, Amita Indah Sitomurni, Diana Nurani, Djatmiko Pinardi, Noorwitri Utami, Nuha Nuha, Sri Peni Wijayanti, Ari Kabul Paminto, Anisa Lutfia, Afifah Nurmala Karima, Hanifah Nisrina, Azalea Eugenie, Rizki Amaliyah, Arief Barkah   +18 more
doaj  

Life cycle assessment of organic chocolate production in Peru

Cleaner Environmental Systems
Limited studies have been conducted in Latin America related to the environmental profile of cocoa and chocolate production using Life Cycle Assessment (LCA). The current study conducts a cradle-to-gate LCA of the production of organic chocolate products
Ian Vázquez-Rowe, Patricia Mogrovejo, Eizo Muñoz-Sovero, Pablo González-Socorro, Jhonnatan Murga, Shenali Madhanaroopan, Salma Fotovat, Taylor Stanley, Karin Bartl, Isabel Quispe   +9 more
doaj   +1 more source

Life Cycle Assessment Practices: Benchmarking Selected European Automobile Manufacturers [PDF]

With the rise of environmental concerns in the general public, re-appropriated by influential politicians, Life Cycle Assessment (LCA) has become a widely used set of tools for the management of all impacts on environment by industrial products.
Jean-Jacques Chanaron
core  

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

A comparative nutritional life cycle assessment of processed and unprocessed soy-based meat and milk alternatives including protein quality adjustment

Frontiers in Sustainable Food Systems
Efforts towards sustainable food systems have stimulated the development of plant-based alternatives to meat and milk. However, the debate on the nutritional quality of (processed) plant products compared to animal products remains unresolved, and ...
Moritz Herrmann, Eric Mehner, Lotti Egger, Reto Portmann, Laila Hammer, Laila Hammer, Laila Hammer, Thomas Nemecek   +7 more
doaj   +1 more source

Simulation aided life cycle sustainability assessment framework for manufacturing design and management [PDF]

, 2016
Decision making for sustainable manufacturing design and management requires critical considerations due to the complexity and partly conflicting issues of economic, social and environmental factors.
Gbededo, Mijoh Ayodele, Liyanage, Kapila, Oraifige, Ilias   +2 more
core   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Organic farming without fossil fuels - life cycle assessment of two Swedish cases [PDF]

, 2013
Organic agriculture is dependent on fossil fuels, just like conventional agriculture, but this can be reduced by the use of on-farm biomass resources. The energy efficiency and environmental impacts of different alternatives can be assessed by life cycle
Baky, A., Hansson, P.-A., Kimming, M., Nordberg, Å., Sundberg, C.   +4 more
core