Results 181 to 190 of about 1,917,255 (320)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Sustainable and accessible hemodialysis: life cycle assessment on central acid delivery system. [PDF]

BMC Nephrol
Tsai CL, Fehintola A, Crooijmans G, Vollenbroek J, Duane B, Gerritsen K.   +5 more
europepmc   +1 more source

Plastic litter in life cycle assessment: Advances of the marine impacts in life cycle assessment international taskforce and application to case studies

Anne-Marie Boulay, Ian Vázquez Rowe, Francesca Verones   +2 more
openalex   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Insights from Life Cycle Assessment to Inform Chemical Substitution, Alternatives Assessment and Safe and Sustainable-by-Design. [PDF]

Environ Sci Technol
Fantke P, Mankong P.
europepmc   +1 more source

Life Cycle Assessment of Spring Frost Protection Methods: High and Contrasted Environmental Consequences in Vineyard Management [PDF]

Vincent Baillet, Ronan Symoneaux, Christel Renaud-Gentié   +2 more
openalex   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Commentary: Non-linearity in LCA – What are we talking about?

Frontiers in Sustainability, 2022
Reinout Heijungs, Reinout Heijungs, Sangwon Suh, Sangwon Suh   +3 more
doaj   +1 more source

A Systematic Review of Nutraceuticals from the Perspective of Life-Cycle Assessment. [PDF]

Pharmaceuticals (Basel)
Djekic I, Smigic N, Vitali Čepo D.
europepmc   +1 more source

ACCOUNTING FOR THE ENVIRONMENTAL IMPACTS ASSOCIATED WITH RESIDUAL PRODUCTS IN A COMPARATIVE LIFE CYCLE ASSESSMENT OF SYSTEMS WITH MULTIPLE PRODUCTS

, 2018
Yasuhiro Fukushima, Satoshi Ohara, Process Development Laboratories, Asahi Group Holdings   +2 more
openalex   +2 more sources