Results 81 to 90 of about 1,917,255 (320)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Life cycle assessment of biofuels from Jatropha curcas in West Africa: a field study [PDF]

, 2009
In recent years, liquid biofuels for transport have benefited from significant political support due to their potential role in curbing climate change and reducing our dependence on fossil fuels.
Achten, Achten, Cuhna Da Silveira, EIA, Eijck, Fargione, Farrell, Foidl, Foidl, Forster, Francis, Fulton, Goel, Grimm, Gübitz, Hill, IEA, ISO 14040, ISO 14044, Kaushik, Kojima, Makkar, Martin, Ogunwole, Openshaw, Prueksakornand, Quirrin, Spaan, Tewari, Vaitilingom, World Bank   +30 more
core   +5 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Exploring the potential of water hyacinth weed (Pontederia crassipes) as an environmentally friendly antifungal to realize sustainable development in lakes: A review

Case Studies in Chemical and Environmental Engineering
Pontederia crassipes is an invasive plant in all aquatic environment, especially in stagnant water such as lakes. This plant contains bioactive compounds with environmentally friendly antifungal properties.
Rita Dwi Ratnani, Forita Dyah Arianti, Nugroho Adi Sasongko   +2 more
doaj   +1 more source

LNG Supply Chains: A Supplier-Specific Life-Cycle Assessment for Improved Emission Accounting [PDF]

, 2021
Selina Roman-White, James Littlefield, Kaitlyn G. Fleury, David T. Allen, Paul Balcombe, Kate Konschnik, J. Jackson Ewing, Gregory B. Ross, Fiji George   +8 more
openalex   +1 more source

Life cycle assessment for the impact assessment of policies [PDF]

, 2016
The European Communication on Better regulation (CEC, 2015) has been complemented with a Better Regulation toolbox which lists models and methods for the impact assessment of policies.
CRISTOBAL GARCIA JORGE, MARELLI Luisa, PANT Rana, REALE FRANCESCA, SALA SERENELLA   +4 more
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Evaluating the impacts of environmental and human health of the critical minerals mining and processing industries in Indonesia using life cycle assessment

Case Studies in Chemical and Environmental Engineering
The critical minerals industries in Indonesia may pose possible environmental and human health risks due to the release of pollutants into soil, water, and air, as well as the use of materials and energy.
Yoyon Wahyono, Nugroho Adi Sasongko, Allan Trench, Martin Anda, Hadiyanto Hadiyanto, Nyayu Aisyah, Anisah Anisah, Novy Ariyanto, Isnaeni Kumalasari, Virny Zasyana Eka Putri, Mutia Citrawati Lestari, Lambas Parlaungan Panggabean, Rohmadi Ridlo, Sundari Sundari, Anissa Dewi Suryaningtyas, Endah Dwi Novianti, Muhammad Raihan Farras Hakim, Anggara Lomak Prihatin, Hashfi Hawali Abdul Matin   +18 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Gearbox life cycle assessment [PDF]

, 2015
Sustainable production has been attracting more and more attention nowadays. Gearbox is a widely applied mechanical engineering product. However, little work of life cycle assessment (LCA) aimed at the gearbox could be found in the literature. This paper
Ren, Z, Su, D
core