Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Maintaining Health in Later Life: Perspectives of Older Indian Migrants in Melbourne, Australia. [PDF]
Health Promot J AustrSandhu S, Gupta S, Wilding R.
europepmc +1 more source
FEBS Letters, EarlyView.Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley +1 more source
Life expectancy of cancer patients in China. [PDF]
Mil Med ResXia CF, Yang J, Zhou JH, Xu YJ, Chen WQ.
europepmc +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Nature Connectedness and Work Engagement in the Relationship Between Emotional Exhaustion and Life Satisfaction Among Employees. [PDF]
Eur J Investig Health Psychol EducJaime-Jorge S +4 more
europepmc +1 more source
Exploring the Social and Cultural Influences on Advance Care Planning Engagement for Patients Living With Cancer: A Hermeneutic Phenomenology Study. [PDF]
Nurs InqLin CP, Huang CY, Peng JK, Chang HT.
europepmc +1 more source
Psychosocial pathways linking type D personality traits to quality of life in patients with permanent intestinal stomas: a cross-sectional structural equation modeling study. [PDF]
Front Med (Lausanne)Tan C, Zhang H, Jiang Y, Zhang Y, Yu M.
europepmc +1 more source
Determining the quality of life-aged care consumer threshold to identify good quality of life in older adults in long-term care. [PDF]
Qual Life ResSong J, Ratcliffe J, Milte R, Khadka J.
europepmc +1 more source